{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:47:17Z","timestamp":1777895237104,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>Obesity is a worldwide health problem in children as well as adults. There is a relationship between oxidative stress, oxidant-antioxidant imbalance and excessive fat accumulation in visceral tissue. Oxidative stress was shown to be an important role in the development of many obesity-related metabolic disorders. Sestrin-2 is an antioxidant protein induced by oxidative stress, and protects cells against reactive oxygen radicals. Thirty obese children with insulin resistance, 29 obese children without insulin resistance between 10-18 years old and 30 healthy gender and age matched control group were included in the study. Children with a body mass index Z-score above 2, comprised the obesity group. HOMA-IR value above 3.16 was accepted as insulin resistance. Sestrin-2 levels and routine laboratory examinations were studied in these three groups. Body mass index, insulin, HOMA-IR, ALT, total cholesterol, LDL, triglyceride, C-reactive protein, waist circumference, systolic blood pressure, diastolic blood pressure, white blood cell count and uric acid levels were significantly higher in insulin resistance group than control. C-reactive protein, diastolic blood pressure and uric acid levels were found to be higher in both groups compared to the control group. Sestrin-2 levels were elevated in obese children with insulin resistance. Clinical trials number: NCT06779721.<\/jats:p>","DOI":"10.1177\/10815589251359311","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T07:54:20Z","timestamp":1751874860000},"page":"254-259","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sestrin-2 levels and insulin resistance in childhood obesity"],"prefix":"10.1177","volume":"74","author":[{"given":"Pembe","family":"Soylu Ustkoyuncu","sequence":"first","affiliation":[{"name":"Pediatric Nutrition and Metabolism Clinic, Kayseri City Training and Research Hospital, Health Sciences University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Kocer","sequence":"additional","affiliation":[{"name":"Biochemistry Clinic, Kayseri City Training and Research Hospital, Health Sciences University, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-s273"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2329C"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2015-0395"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000342642"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.08.004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-6051-9_6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.11.002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1044976"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.028"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/505849"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.03.023"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.010857"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.043497"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1921"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0502-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00829-z"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1120929"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165838"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3529"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.07.024"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.897965"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.07.020"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.11.015"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5233"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/chi.2017.0082"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.12.027"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251359311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10815589251359311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251359311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:31Z","timestamp":1777459231000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10815589251359311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/10815589251359311"],"URL":"https:\/\/doi.org\/10.1177\/10815589251359311","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]}}}