{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:26:44Z","timestamp":1784780804225,"version":"3.55.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Surgical treatments for drug-refractory gastroparesis (GP) include gastric electrical stimulation (GES) and pyloric interventions. No longitudinal studies have evaluated the clinical outcomes and safety of combined GES and pyloroplasty (PP). We aimed to investigate the long-term clinical effectiveness of concurrent utilization of GES and PP in GP. Forty-nine gastroparetics (35 female; 38 diabetics [DM]) were enrolled and followed up. Baseline and follow-up total symptom scores (TSS) and individual symptom components were assessed, and a 4-hour scintigraphy gastric emptying test (GET) was performed. Hospitalization days, medication use, HbA1c level, and serious adverse events (SAE) were recorded. The median follow-up was 47\u2009months (range 5\u201390). Mean TSS was significantly reduced from 18.6 to 6.2\u2009points (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009\u2264\u2009.001). GET mean retention of isotope-labeled meal was reduced from 74% to 47% at 2\u2009h and from 47% to 19% at 4\u2009h (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.01). Mean HbA1c improved from 9.0 to 7.9. Annual hospitalization days were reduced from a mean of 25 to 2 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u2009.05). The overall satisfaction rate was subjectively graded as 87% by the patients. There were no immediate complications; SAEs attributed to GES occurred in 9% of patients. Based on this study, combining GES with PP shows long-term: (a) improvement in GP symptoms and a high patient satisfaction rate; (b) acceleration and in some patients\u2019 normalization of gastric emptying; (c) a decrease in hospitalizations; and (d) an acceptable safety and SAE profile.\n                  <\/jats:p>","DOI":"10.1177\/10815589251366904","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T12:14:18Z","timestamp":1754655258000},"page":"449-457","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The long-term outcomes of combining pyloroplasty with gastric electrical stimulation in drug-refractory gastroparesis: A prospective single-arm trial"],"prefix":"10.1177","volume":"74","author":[{"given":"Irene","family":"Sarosiek","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Bashashati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorisadday","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamis","family":"Bright","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Texas Tech University Health Sciences Center, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Espino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameson","family":"Forster","sequence":"additional","affiliation":[{"name":"University of Missouri \u2013 Kansas City School of Medicine, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Department of Surgery, Texas Tech University Health Sciences Center, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Sarosiek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Radiology; Texas Tech University Health Sciences Center, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Padilla","sequence":"additional","affiliation":[{"name":"Department of Pathology, Texas Tech University Health Sciences Center, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Davis","sequence":"additional","affiliation":[{"name":"Christus Trinity Clinic, Corpus Christi, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"McCallum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"issue":"5","key":"e_1_3_3_2_2","article-title":"American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis","volume":"127","author":"Parkman HP","year":"2004","unstructured":"Parkman HP, Hasler WL, Fisher RS. 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