{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:16:49Z","timestamp":1784924209017,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Coronary collateral circulation (CCC) plays a vital compensatory role in patients with type 2 diabetes mellitus (T2DM) and obstructive coronary artery disease (CAD). However, impaired collateral development is common in T2DM, and therapeutic strategies to enhance CCC are underexplored. We aimed to evaluate the association between sodium-glucose cotransporter-2 inhibitor dapagliflozin use and coronary collateral development in T2DM patients with obstructive CAD. This cross-sectional study evaluated 59 T2DM patients undergoing coronary angiography for total coronary occlusion. CCC was graded using the Rentrop classification, and patients were divided into poor and good CCC groups. Propensity score matching (PSM) and multivariate logistic regression analyses were performed to identify independent predictors of good CCC. Good CCC was observed in 74.6% of patients. Dapagliflozin use was significantly more common among patients with good CCC (81.8% vs 13.3%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In multivariate analysis, dapagliflozin use was significantly associated with good CCC (odds ratio: 32.5; 95% confidence interval (CI): 5.21\u2013642,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.002). After PSM, the dapagliflozin use remained a significant predictor. ROC analysis demonstrated strong discriminative ability (AUC: 0.821; 95% CI: 0.711\u20130.932). Dapagliflozin use is likely associated with enhanced coronary collateral development in T2DM patients with obstructive CAD, indicating a possible mechanism underlying its cardioprotective effects beyond glycemic control.\n                  <\/jats:p>","DOI":"10.1177\/10815589251382270","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:58:10Z","timestamp":1757908690000},"page":"458-467","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between dapagliflozin use and coronary collateral circulation in patients with type 2 diabetes: A hypothesis-generating study"],"prefix":"10.1177","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-8002","authenticated-orcid":false,"given":"Gokhan","family":"Koker","sequence":"first","affiliation":[{"name":"Antalya Training and Research Hospital, Ministry of Health, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Sahinturk","sequence":"additional","affiliation":[{"name":"Antalya Training and Research Hospital, Ministry of Health, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9203-2285","authenticated-orcid":false,"given":"Muhammed Ali","family":"Coskuner","sequence":"additional","affiliation":[{"name":"Antalya Training and Research Hospital, Ministry of Health, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfullah Zahit","family":"Koc","sequence":"additional","affiliation":[{"name":"Antalya Training and Research Hospital, Ministry of Health, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Han","family":"Kumas","sequence":"additional","affiliation":[{"name":"Antalya Training and Research Hospital, Ministry of Health, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Zorlu Gorgulugil","sequence":"additional","affiliation":[{"name":"Antalya Training and Research Hospital, Ministry of Health, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5795-533X","authenticated-orcid":false,"given":"Bilgin Bahadir","family":"Basgoz","sequence":"additional","affiliation":[{"name":"Antalya Training and Research Hospital, Ministry of Health, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-4366","authenticated-orcid":false,"given":"Nizameddin","family":"Koca","sequence":"additional","affiliation":[{"name":"TC Saglik Bakanligi Bursa Sehir Hastanesi, Nil\u00fcfer, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008499"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.08.014"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01033-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065118.99409.5F"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.956086"},{"key":"e_1_3_2_8_2","first-page":"800","article-title":"Predictors, treatment, and long-term outcomes of coronary perforation during retrograde percutaneous coronary intervention via epicardial collaterals for recanalization of chronic coronary total occlusion","volume":"93","author":"Wu K","year":"2019","unstructured":"Wu K, Huang Z, Zhong Z, et al. Predictors, treatment, and long-term outcomes of coronary perforation during retrograde percutaneous coronary intervention via epicardial collaterals for recanalization of chronic coronary total occlusion. Catheter Cardiovasc Interv 2019; 93(S1): 800\u2013809.","journal-title":"Catheter Cardiovasc Interv"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00187-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0671-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.104058"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01297-4"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.058"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001917"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812389"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32590-X"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13266"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz486"},{"key":"e_1_3_2_21_2","article-title":"Cardiovascular disease and risk management: standards of medical care in diabetes\u20142022","volume":"45","author":"American Diabetes Association Professional Practice Committee. 10","year":"2022","unstructured":"American Diabetes Association Professional Practice Committee. 10. Cardiovascular disease and risk management: standards of medical care in diabetes\u20142022. Diabetes Care 2022; 45(suppl 1): S144\u2013S174.","journal-title":"Diabetes Care"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80380-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01607-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073651"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.33594\/000000178"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-67195-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.015"},{"issue":"5","key":"e_1_3_2_28_2","first-page":"761","article-title":"Dapagliflozin improves angiogenesis after hindlimb ischemia through the PI3K\u2013Akt\u2013eNOS pathway","volume":"14","author":"Xu L","year":"2024","unstructured":"Xu L, Ouyang S, Liu B, et al. Dapagliflozin improves angiogenesis after hindlimb ischemia through the PI3K\u2013Akt\u2013eNOS pathway. Biomolecules 2024; 14(5): 761.","journal-title":"Biomolecules"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0816-2"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.039996"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911303"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/1479164117733626"},{"key":"e_1_3_2_33_2","first-page":"100331","article-title":"Oncostatin M mediates cardioprotection via angiogenesis in ischemic heart disease","volume":"35","author":"Ikeda S","year":"2023","unstructured":"Ikeda S, Sato K, Takeda M, et al. Oncostatin M mediates cardioprotection via angiogenesis in ischemic heart disease. Am Heart J Plus 2023; 35: 100331.","journal-title":"Am Heart J Plus"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.05.002"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251382270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10815589251382270","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251382270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:25:46Z","timestamp":1778761546000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10815589251382270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/10815589251382270"],"URL":"https:\/\/doi.org\/10.1177\/10815589251382270","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]}}}