{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:09:21Z","timestamp":1778764161906,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Thallium-201 scintigraphy can detect microvascular diseases; however, the correlation between cardiac amyloidosis and thallium-201 scintigraphy findings is unknown. We aimed to investigate the influence of amyloid deposition on thallium-201 scintigraphy. We retrospectively analyzed individuals with cardiac amyloidosis at National Taiwan University Hospital, reviewing baseline characteristics, biochemistry, echocardiography, thallium-201 scintigraphy, and coronary angiography. Thirty-six participants were enrolled, of whom 32 had transthyretin amyloid cardiomyopathy. The left ventricular (LV) posterior wall thickness was 13.71\u2009\u00b1\u20092.45\u2009mm, and the summed stress score (SSS) and summed difference score (SDS) on thallium-201 scintigraphy were 5.47\u2009\u00b1\u20096.42 and 2.16\u2009\u00b1\u20092.13, respectively. Abnormal thallium-201 scintigraphy findings were observed in 72.22% of patients. In Spearman\u2019s correlation analysis, both the SSS and summed difference score (SDS) were significantly correlated with LV posterior wall thickness (SSS:\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.43,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.008; SDS:\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.50,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.002). In multivariable analysis, LV posterior wall thickness remained the only significant predictor of SSS (\u03b2\u2009=\u20090.410, 95% CI: 0.250\u20131.895,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.012). Coronary angiography was performed in eight of the patients with abnormal thallium-201 scintigraphy, none of whom had physiologically significant coronary artery lesions. Abnormal thallium-201 scintigraphy findings were common in the patients with cardiac amyloidosis, even though they did not have significant epicardial coronary lesions. Furthermore, SSS was associated with LV posterior wall thickness. These results suggest that thallium-201 scintigraphy may help identify myocardial perfusion abnormalities related to cardiac amyloidosis, particularly in patients presenting with unexplained LV hypertrophy and nonobstructive coronary arteries.\n                  <\/jats:p>","DOI":"10.1177\/10815589251384949","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T11:54:32Z","timestamp":1758714872000},"page":"468-477","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Perfusion defects on thallium-201 scintigraphy in cardiac amyloidosis"],"prefix":"10.1177","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-7442","authenticated-orcid":false,"given":"Yi-Hsin","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Li","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Lun","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"},{"name":"Department of Biomedical Engineering, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao-Yuan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan"},{"name":"Department of Medical Imaging and Radiological Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Tung","family":"Shun","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Pathology, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Chao","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Tsang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Huei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsueh-Wen","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy Jyh-Ming","family":"Juang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hsuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"},{"name":"Cardiovascular 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