{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:39:22Z","timestamp":1791826762821,"version":"4.3.4"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Science and Technology Research Project of Guangdong Provincial Hospital of Chinese Medicine","award":["YN2022MS05"],"award-info":[{"award-number":["YN2022MS05"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"abstract":"<jats:p>This study conducted a meta-analysis to evaluate the efficacy and safety of neuromodulators in treating refractory or unexplained chronic cough (R\/UCC), given the limited treatment options and concerns about medication safety. Nine randomized controlled trials were included, focusing on the impact of neuromodulators on chronic cough symptoms. Results showed significant improvements in quality of life, with a mean difference (MD) in the Leicester Cough Questionnaire score of 3.21 and a reduction in 24-h cough frequency with an MD of \u22127.91. Gabapentin demonstrated the most substantial enhancements. Longer treatment durations, specifically 12\u2009weeks, were found to be more effective. Sensitivity analysis and publication bias assessment confirmed the reliability of these findings, indicating the clinical efficacy of neuromodulators in managing R\/UCC. Future research should investigate patient population differences and treatment strategies to expand the broader application of neuromodulators in the management of chronic cough.<\/jats:p>","DOI":"10.1177\/10815589251406268","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:42:51Z","timestamp":1764333771000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Gabapentin in chronic cough treatment: Meta-analysis insights"],"prefix":"10.1177","author":[{"given":"Dongxu","family":"Si","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine II, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"He","sequence":"additional","affiliation":[{"name":"Guangzhou Red Cross Hospital, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine II, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingna","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine II, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine II, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine II, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-022-02171-z"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0127-2021"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02348-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-022-01847-w"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-030945"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-054832"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00113-2018"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00099-2016"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00069-2022"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-2-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-015-9701-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00105-2021"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-022-00770-9"},{"issue":"5","key":"e_1_3_3_15_2","first-page":"59","article-title":"Chronic cough","volume":"119","author":"Kruger K","year":"2022","unstructured":"Kruger K, Holzinger F, Trauth J, et al. Chronic cough. Dtsch Arztebl Int 2022; 119(5): 59\u201365.","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-022-00592-5"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2309906"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/atm.atm_105_23"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2022.02.005"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871527322666221102141002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96608-w"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.10.017"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02203-2018"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207425"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2020-icc-007"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201912-2347OC"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01615-2019"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.05.015"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1414215"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1481"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102100"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1462795"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25186"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70043-2"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00546-2021"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2020-icc-002"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1271"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000244377.60334.e3"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2023.103815"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2020.013"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60776-4"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-023-00621-x"},{"issue":"01","key":"e_1_3_3_45_2","first-page":"31","article-title":"Efficacy observation of acupuncture combined with medication for chronic cough after lung surgery","volume":"43","author":"Chen Y","year":"2024","unstructured":"Chen Y, Xie M, Wu S, et al. Efficacy observation of acupuncture combined with medication for chronic cough after lung surgery. Shanghai J Acupuncture Moxibustion 2024; 43(01): 31\u201335.","journal-title":"Shanghai J Acupuncture Moxibustion"},{"issue":"5","key":"e_1_3_3_46_2","first-page":"665","article-title":"The efficiency and safety of gabapentin in the treatment of pertinacious chronic cough","volume":"22","author":"Li T","year":"2016","unstructured":"Li T, Cai N. The efficiency and safety of gabapentin in the treatment of pertinacious chronic cough. Int Med Health Herald 2016; 22(5): 665\u2013668.","journal-title":"Int Med Health Herald"},{"issue":"17","key":"e_1_3_3_47_2","first-page":"37","article-title":"Baclofen for treating children with refractory gastroesophageal reflux induced cough in 40 cases","volume":"24","author":"Huang J","year":"2015","unstructured":"Huang J, Wu S. Baclofen for treating children with refractory gastroesophageal reflux induced cough in 40 cases. China Pharm 2015; 24(17): 37\u201338.","journal-title":"China Pharm"},{"issue":"01","key":"e_1_3_3_48_2","first-page":"150","article-title":"Efficacy observation of Baclofen in treating refractory cough related to gastroesophageal reflux disease","volume":"29","author":"Wu W","year":"2017","unstructured":"Wu W, Zhang H, Zhang Z, et al. Efficacy observation of Baclofen in treating refractory cough related to gastroesophageal reflux disease. Strait Pharm J 2017; 29(01): 150\u2013151.","journal-title":"Strait Pharm J"},{"issue":"5","key":"e_1_3_3_49_2","first-page":"51","article-title":"Efficacy of neuro-modulators applied at different stages in the treatment of gastroesophageal reflux cough","author":"Huang S","year":"2024","unstructured":"Huang S, Wu F. Efficacy of neuro-modulators applied at different stages in the treatment of gastroesophageal reflux cough. Mingyi J 2024; (5): 51\u201353.","journal-title":"Mingyi J"},{"issue":"17","key":"e_1_3_3_50_2","first-page":"21","article-title":"Observation on the efficacy of baclofen combined with omeprazole and mosapride in the treatment of refractory gastroesophageal reflux cough in children","volume":"23","author":"Lin Z","year":"2016","unstructured":"Lin Z, Pan H, Zhong X. Observation on the efficacy of baclofen combined with omeprazole and mosapride in the treatment of refractory gastroesophageal reflux cough in children. Chin J Rural Med Pharm 2016; 23(17): 21\u201322.","journal-title":"Chin J Rural Med Pharm"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2022.43.220022"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2022.2065142"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2021.102859"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015916"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.06.007"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2024.107582"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251406268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10815589251406268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251406268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:42Z","timestamp":1777459242000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10815589251406268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":55,"alternative-id":["10.1177\/10815589251406268"],"URL":"https:\/\/doi.org\/10.1177\/10815589251406268","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"article-number":"10815589251406268"}}