{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:21:51Z","timestamp":1788175311770,"version":"build-2803163510"},"reference-count":87,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    The aim of this study is to investigate the association of delirium with laboratory-derived indices and ratios in patients staying in an intensive care unit. Delirium was diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria, and laboratory data obtained at the time of diagnosis were retrospectively analyzed. The following indices were calculated: C-reactive protein (CRP)\/albumin ratio (CAR), CRP\u2013albumin\u2013lymphocyte, B12\u2013CRP index, systemic immune\u2013inflammation, Prognostic Nutritional Index, advanced lung cancer inflammation, Systemic Inflammation Response Index, and Glasgow Prognostic Score. In addition, inflammation markers derived from the complete blood count were also analyzed. They were compared between patients with and without delirium. The study included 215 patients, of whom 104 had delirium (median age 76\u2009years, 51.6% females). Patients with delirium were older than those without delirium (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.008). The median CAR index was higher in patients with delirium (3.4\u2009mg\/g, 0.02\u201328.23) compared to those without delirium (2.19\u2009mg\/g, 0.02\u201316.74), with borderline statistical significance (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.071). No statistically significant differences were found in other indices and laboratory parameters between patients with delirium and those without it (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05 for all). When patients were stratified into tertiles based on CAR levels, the occurrence of delirium was significantly higher in the third tertile than in the other two tertiles (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.020). Even after adjusting for all significant confounding factors, CAR remained independently associated with delirium (odds ratio: 1.099, 95% confidence interval: 1.002\u20131.205,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.046). The findings of this study suggest that the CAR index may serve as an independent associated factor for delirium compared to other laboratory-derived markers in critically ill patients.\n                  <\/jats:p>","DOI":"10.1177\/10815589261415891","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T04:21:16Z","timestamp":1768191676000},"page":"698-708","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The CRP\/albumin ratio (CAR) may be more strongly linked to delirium than other indices derived from laboratory parameters in older patients in an intensive care unit"],"prefix":"10.1177","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7094-8387","authenticated-orcid":false,"given":"Merve","family":"Yilmaz Kars","sequence":"first","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Hamidiye School of Medicine, Konya City Hospital, University of Health Sciences Turkey, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyas","family":"Akkar","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Hamidiye School of Medicine, Konya City Hospital, University of Health Sciences Turkey, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9979-691X","authenticated-orcid":false,"given":"Mustafa Hakan","family":"Dogan","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Hamidiye School of Medicine, Konya City Hospital, University of Health Sciences Turkey, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1607-0712","authenticated-orcid":false,"given":"Zeynep Iclal","family":"Turgut","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Hamidiye School of Medicine, Konya City Hospital, University of Health Sciences Turkey, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1918-8544","authenticated-orcid":false,"given":"Orhan","family":"Cicek","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Hamidiye School of Medicine, Konya City Hospital, University of Health Sciences Turkey, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Dikmeer","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Hamidiye School of Medicine, Konya City Hospital, University of Health Sciences Turkey, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-724X","authenticated-orcid":false,"given":"Korhan","family":"Kollu","sequence":"additional","affiliation":[{"name":"Division of Intensive Care Medicine, Department of Internal Medicine, Hamidiye School of Medicine, Konya City Hospital, University of Health Sciences Turkey, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru Cagri","family":"Cakir Ozden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hamidiye School of Medicine, Konya City Hospital, University of Health Sciences Turkey, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-6811","authenticated-orcid":false,"given":"Muhammet Cemal","family":"Kizilarslanoglu","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Hamidiye School of Medicine, Konya City Hospital, University of Health Sciences Turkey, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Book review. 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