{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T08:03:10Z","timestamp":1780128190647,"version":"3.54.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"abstract":"<jats:p>\n                    Age is one of the most critical non-modifiable risk factors for stroke. With the increasing aging of the global population, the incidence of stroke is expected to increase. The current evidence makes treatment decisions regarding MT in patients over 90\u2009years of age challenging. The aim of this study is to evaluate the efficacy of mechanical thrombectomy (MT) and the factors associated with outcomes in patients aged 90\u2009years and older. This is an observational study that follows STROBE guidelines. Patients aged 90\u2009years and older with a pre-stroke Modified Rankin Scale (mRS) score of 0\u20131 a proximal large-vessel occlusion, who did not receive IV tPA were included in the study. A total of 28 patients were included. To assess clinical outcomes, the 90-day mRS score was evaluated. Patients were categorized into two groups: good clinical outcome (mRS 0\u20132) and poor clinical outcome (mRS 3\u20136). The mean age was 91.2\u2009\u00b1\u20091.5\u2009years. Female patients accounted for 71.4%. The mean National Institutes of Health Stroke Scale (NIHSS) score was 18.7\u2009\u00b1\u20094.3. Hypertension was the most common comorbidity. The admission glucose levels were significantly higher in the poor clinical outcome group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.03). Type 3 aortic arch was significantly more frequent in the group with poor clinical outcomes. Isolated middle cerebral artery (MCA) occlusion was significantly more common in the good clinical outcome group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.03). Our findings suggest that MT can be successful in certain nonagenarian patients. In this study, we identified that admission blood glucose level, aortic arch morphology, location of the occluded vessel, and puncture-to-recanalization time are determinant factors for clinical outcomes.\n                  <\/jats:p>","DOI":"10.1177\/10815589261451177","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:01:22Z","timestamp":1778047282000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute stroke treatment with mechanical thrombectomy without IV tPA in nonagenarian patients: A single-center experience"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-9405","authenticated-orcid":false,"given":"Sena","family":"Boncuk Ula\u015f","sequence":"first","affiliation":[{"name":"University of Lille, Research Master in Neuroscience (MD, Neurologist), Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6896-4660","authenticated-orcid":false,"given":"Vasfiye","family":"Sezer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5310-2498","authenticated-orcid":false,"given":"Ay\u015fe Kristina","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3851-6500","authenticated-orcid":false,"given":"Esra","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4979-3684","authenticated-orcid":false,"given":"Halil Alper","family":"Eryilmaz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7018-5266","authenticated-orcid":false,"given":"Derya","family":"Kara Gen\u00e7","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya Training and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-914X","authenticated-orcid":false,"given":"T\u00fcrkan","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya University Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-8056","authenticated-orcid":false,"given":"Ye\u015fim","family":"G\u00fczey Aras","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya University Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-2152","authenticated-orcid":false,"given":"Bilgehan At\u0131lgan","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sakarya University Faculty of Medicine, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.741754"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106354"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2020.07.008"},{"issue":"6","key":"e_1_3_2_5_2","first-page":"1846","article-title":"Should coronary catheter laboratories be used in the treatment of ischemic stroke? Endovascular treatment in acute ischemic stroke performed by interventional cardiologists","volume":"26","author":"Kocayigit I","year":"2022","unstructured":"Kocayigit I, Kilic H, Acar BA, et al. Should coronary catheter laboratories be used in the treatment of ischemic stroke? Endovascular treatment in acute ischemic stroke performed by interventional cardiologists. Eur Rev Med Pharmacol Sci 2022; 26(6): 1846\u20131851.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.36"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Kawaji H Tomoto K Arakawa T et al. Feasibility of mechanical thrombectomy for acute ischemic stroke patients aged 90 years or older compared to younger patients. 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