{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:25:15Z","timestamp":1788391515107,"version":"build-2803163510"},"reference-count":0,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study evaluated the clinical value of combined T\u2011lymphocyte subset, immunoglobulin, and complement testing in assessing treatment efficacy and prognosis in connective tissue disease\u2011associated interstitial lung disease (CTD\u2011ILD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 110 CTD\u2011ILD patients, 90 CTD patients without ILD, and 110 healthy controls were enrolled. High\u2011resolution chest CT and lung function tests were performed in CTD\u2011ILD and CTD patients. Serum CD4+, CD8+, IgA, IgG, IgM, C3, and C4 levels were measured. CTD\u2011ILD patients received prednisone plus cyclophosphamide and were categorized into good\/poor efficacy groups and good\/poor prognosis groups after 6\u2011month follow\u2011up. Independent risk factors for poor prognosis were identified by logistic regression, and ROC analysis assessed the predictive value of combined indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared with CTD and control groups, CTD\u2011ILD patients had reduced lung function, lower T\u2011lymphocyte subsets, elevated immunoglobulin, and reduced complements (P &lt; 0.05). Poor efficacy and poor prognosis groups showed lower CD4+\/CD8+ levels, higher immunoglobulins, and lower complements than their counterparts (P &lt; 0.05). CD8+, IgA, C3, and C4 were independent predictors of treatment efficacy, while CD4+, CD8+, IgA, C3, and C4 independently predicted prognosis. ROC analysis confirmed the combined assay\u2019s predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Combined measurement of T\u2011lymphocyte subsets, immunoglobulins, and complements provides significant predictive information for treatment response and prognosis in CTD\u2011ILD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10815589261473285","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:20:31Z","timestamp":1784874031000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["EXPRESS: Value of T-lymphocyte subsets, immunoglobulin, and complements in assessing efficacy and prognosis of connective tissue disease-associated interstitial lung disease"],"prefix":"10.1177","author":[{"given":"Junliang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,23]]},"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589261473285","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589261473285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:16:23Z","timestamp":1784967383000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10815589261473285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":0,"alternative-id":["10.1177\/10815589261473285"],"URL":"https:\/\/doi.org\/10.1177\/10815589261473285","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"article-number":"10815589261473285"}}