{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:24:09Z","timestamp":1788531849153,"version":"build-2803163510"},"reference-count":8,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"DOI":"10.1177\/10815589261483682","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:38:40Z","timestamp":1788349120000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune biomarkers in CTD-ILD: Promise, practicality and the path to validation"],"prefix":"10.1177","author":[{"given":"Nadeem","family":"Bandealy","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Wagh","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-977X","authenticated-orcid":false,"given":"Uzair","family":"Ghori","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Antoniou KM Distler O Gheorghiu AM et al. ERS\/EULAR clinical practice guidelines for connective tissue disease-associated interstitial lung disease. Eur Respir J. 2026;67(1):2402533. https:\/\/doi.org\/10.1016\/j.ard.2025.08.021","DOI":"10.1183\/13993003.01973-2025"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Wu AC Kiley JP Noel PJ et al. Current status and future opportunities in lung precision medicine research with a focus on biomarkers: an American Thoracic Society\/National Heart Lung and Blood Institute research statement. Am J Respir Crit Care Med. 2018;198(12):e116\u2013e136. https:\/\/doi.org\/10.1164\/rccm.201810-1895ST","DOI":"10.1164\/rccm.201810-1895ST"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Pugashetti JV Khanna D Kazerooni EA et al. Clinically relevant biomarkers in connective tissue disease-associated interstitial lung disease. Immunol Allergy Clin North Am. 2023;43(2):411\u2013433. https:\/\/doi.org\/10.1016\/j.iac.2023.01.012","DOI":"10.1016\/j.iac.2023.01.012"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Lee JS Lee EY Ha YJ et al. Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease. Arthritis Res Ther. 2019;21(1):58. https:\/\/doi.org\/10.1186\/s13075-019-1835-9","DOI":"10.1186\/s13075-019-1835-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"van Bon L Affandi AJ Broen J et al. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014;370(5):433\u2013443. https:\/\/doi.org\/10.1056\/NEJMoa1114576","DOI":"10.1056\/NEJMc1402401"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Takahashi H Kuroki Y Tanaka H et al. Serum levels of surfactant proteins A and D are useful biomarkers for interstitial lung disease in patients with progressive systemic sclerosis. Am J Respir Crit Care Med. 2000;162(1):258\u2013263. https:\/\/doi.org\/10.1164\/ajrccm.162.1.9903014","DOI":"10.1164\/ajrccm.162.1.9903014"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","unstructured":"Lee JH Jang JH Lee S et al. Immunopathogenic mechanisms in connective tissue disease-associated interstitial lung disease: incessant loop of immunity to fibrosis. Int J Mol Sci. 2025;26(24):12126. https:\/\/doi.org\/10.3390\/ijms262412126","DOI":"10.3390\/ijms262412126"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Yang J Liu L Wang Y et al. Value of T-lymphocyte subsets immunoglobulin and complements in assessing efficacy and prognosis of connective tissue disease-associated interstitial lung disease. J Investig Med. Epub ahead of print 23 July 2026. https:\/\/doi.org\/10.1177\/10815589261473285","DOI":"10.1177\/10815589261473285"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589261483682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10815589261483682","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589261483682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:50:41Z","timestamp":1788529841000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10815589261483682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":8,"alternative-id":["10.1177\/10815589261483682"],"URL":"https:\/\/doi.org\/10.1177\/10815589261483682","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]},"article-number":"10815589261483682"}}