{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:45:30Z","timestamp":1777481130875,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      This study elucidated the role of the forkhead box E1 (\n                      <jats:italic toggle=\"yes\">FOXE1<\/jats:italic>\n                      )\u2013laminin \u03b32 (LAMC2) signaling axis in promoting brain metastasis (BM) of lung cancer and evaluated its potential as a therapeutic target to enhance the efficacy of preoperative chemoradiotherapy (CRT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Bioinformatics analysis of the GSE126548 dataset revealed a significant association between elevated\n                      <jats:italic toggle=\"yes\">FOXE1<\/jats:italic>\n                      expression and BM in lung cancer patients. Functional\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      assays\u2014including real-time polymerase chain reaction, Western blotting, migration, invasion, and endothelial permeability assays\u2014were conducted in lung cancer cells and human umbilical vein endothelial cells exposed to tumor-conditioned media. In addition,\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      xenograft and BM mouse models were established to assess the impact of\n                      <jats:italic toggle=\"yes\">FOXE1<\/jats:italic>\n                      on tumor growth, metastatic potential, and treatment responsiveness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">FOXE1<\/jats:italic>\n                      knockdown significantly inhibited lung cancer cell proliferation, migration, invasion, and epithelial\u2013mesenchymal transition. Mechanistically, LAMC2 was identified as a downstream effector of\n                      <jats:italic toggle=\"yes\">FOXE1<\/jats:italic>\n                      , with rescue experiments confirming that the\n                      <jats:italic toggle=\"yes\">FOXE1<\/jats:italic>\n                      \u2013LAMC2 axis plays a central role in driving tumor progression and brain metastatic potential. Notably,\n                      <jats:italic toggle=\"yes\">FOXE1<\/jats:italic>\n                      silencing enhanced sensitivity to CRT in preclinical models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">FOXE1<\/jats:italic>\n                      promotes lung cancer progression and BM by upregulating LAMC2. Targeting the\n                      <jats:italic toggle=\"yes\">FOXE1<\/jats:italic>\n                      \u2013LAMC2 pathway may improve the efficacy of preoperative CRT and offers a promising strategy for therapeutic intervention in lung cancer patients at high risk of BM.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10849785251366774","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T15:55:03Z","timestamp":1759247703000},"page":"580-592","source":"Crossref","is-referenced-by-count":0,"title":["Targeting\n                    <i>FOXE1<\/i>\n                    -Mediated LAMC2 Expression to Improve Preoperative Chemoradiotherapy Outcomes in Lung Cancer Patients at Risk of Brain Metastasis"],"prefix":"10.1177","volume":"40","author":[{"given":"Yiping","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China."},{"name":"Department of Respiratory and Critical Care Medicine, Nanping First Hospital Affiliated to Fujian Medical University, Nanping, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Nanping First Hospital Affiliated to Fujian Medical University, Nanping, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Nanping First Hospital Affiliated to Fujian Medical University, Nanping, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuhong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Nanping First Hospital Affiliated to Fujian Medical University, Nanping, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaijun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Nanping First Hospital Affiliated to Fujian Medical University, Nanping, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Nanping First Hospital Affiliated to Fujian Medical University, Nanping, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6115-1407","authenticated-orcid":false,"given":"Gengyun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 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