{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:26:51Z","timestamp":1788791211182,"version":"build-2803163510"},"reference-count":134,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>Alkylating agents, characterized by their ability to bind to and modify DNA, have shown promising impacts on breast cancer patients in clinical trials across various stages and phases. This review, utilizing data from the National Library of Medicine\u2019s clinicaltrials.gov, investigates the efficacy of these drugs in breast cancer treatment. The report focuses on cyclophosphamide, an alkylating agent that prevents cancer cell DNA replication, and its synergistic effects when combined with other medications such as docetaxel, a taxane that suppresses cell division. Results indicate that these combination therapies may enhance treatment efficacy and improve outcomes. This survey highlights the widespread use of alkylating agents in clinical studies for breast cancer, a disease affecting over a million people annually in India alone. Commonly used alkylating drugs for breast cancer treatment include carmustine, chlorambucil, and cyclophosphamide. These agents have shown effectiveness in treating metastatic breast cancer and reducing the risk of recurrence, underscoring their significant role in breast cancer therapy.<\/jats:p>","DOI":"10.1177\/10849785251376173","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T07:40:40Z","timestamp":1758094840000},"page":"709-732","source":"Crossref","is-referenced-by-count":3,"title":["An Update on Alkylating Agents in Breast Cancer Therapy"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-6257","authenticated-orcid":false,"given":"Rahaman","family":"Shaik","sequence":"first","affiliation":[{"name":"Department of Pharmacology, St. Paul\u2019s College of Pharmacy, Hyderabad, India."},{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nissy Evengelin","family":"Gera","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Sarwar","family":"Syeda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Syeda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiranmai","family":"Mandava","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, St. Paul\u2019s College of Pharmacy, Hyderabad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Chirumamilla","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoshna","family":"Bontha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research, New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Global Breast Cancer Initiative Implementation Framework: Assessing, Strengthening and Scaling-up of Services for the Early Detection and Management of Breast Cancer","author":"World Health Organization","year":"2023","unstructured":"World Health Organization. Global Breast Cancer Initiative Implementation Framework: Assessing, Strengthening and Scaling-up of Services for the Early Detection and Management of Breast Cancer. World Health Organization; 2023."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2023.06.02"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2022.02.004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612805666230110214512"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3152-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191367098"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13020287"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.3787"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155214531513"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.3062"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-15-0910-0","volume-title":"Stimuli-Responsive carbon nanotubes for targeted drug delivery","author":"Hasnain MS","year":"2019","unstructured":"Hasnain MS, , Ahmad SA, , Hoda MN, et al. Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Application. In: Stimuli-Responsive carbon nanotubes for targeted drug delivery. Elsevier: Amsterdam, The Netherlands; 2019."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.146"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.02.005"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38446.498542.8F"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-068791"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604.ch4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)70727-8"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.72251"},{"issue":"2","key":"e_1_3_3_20_2","first-page":"57","article-title":"Carcinoma in the mammary lobule and its origin","volume":"40","author":"Dawson EK","year":"1933","unstructured":"Dawson EK. Carcinoma in the mammary lobule and its origin. Edinb Med J, 1933; 40(2):57\u201382.","journal-title":"Edinb Med J"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0055-z"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-011-9381-z"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.09.013"},{"key":"e_1_3_3_24_2","volume-title":"UpToDate: UpToDate","author":"Anders CK","year":"2021","unstructured":"Anders CK, , Carey LA, , Burstein HJ. ER\/PR negative, HER2-negative (triple-negative) breast cancer. UpToDate: UpToDate. 2021."},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-403"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1608"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4741.1999.00002.x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0352-5"},{"issue":"7","key":"e_1_3_3_29_2","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/(SICI)1097-0142(19990401)85:7<1547::AID-CNCR16>3.0.CO;2-2","article-title":"Incidence and distribution pattern of pelvic and paraaortic lymph node metastasis in patients with Stages IB, IIA, and IIB cervical carcinoma treated with radical hysterectomy","volume":"85","author":"Sakuragi N","year":"1999","unstructured":"Sakuragi N, , Satoh C, , Takeda N, et al. Incidence and distribution pattern of pelvic and paraaortic lymph node metastasis in patients with Stages IB, IIA, and IIB cervical carcinoma treated with radical hysterectomy. Cancer: Interdisciplinary Intr J American Cancer Society, 1999; 85(7):1547\u20131554.","journal-title":"Cancer: Interdisciplinary Intr J American Cancer Society"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.2301"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70938-X"},{"issue":"8","key":"e_1_3_3_32_2","first-page":"1315","article-title":"The mechanism of action of alkylating agents","volume":"23","author":"Warwick GP","year":"1963","unstructured":"Warwick GP. The mechanism of action of alkylating agents. Cancer Res, 1963; 23(8_Part_1):1315\u20131333.","journal-title":"Cancer Res"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612805666230110214938"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3185"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082051"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153819"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16723"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-9704-0_4"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.963077"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401894"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199512000-00007"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2022.8325"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1159\/000335199"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1177\/17588359211042301"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.0085"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.513"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30447-2"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-13278-5"},{"key":"e_1_3_3_49_2","volume-title":"Chemistry and Mechanism of Action","author":"CH R, CH R. 2","year":"1996","unstructured":"CH R, CH R. 2. Chemistry and Mechanism of Action. Cancer Therapeutics: Experimental and Clinical Agents; 1996."},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.17.9.1061"},{"issue":"3","key":"e_1_3_3_51_2","first-page":"243","article-title":"Trastuzumab: Targeted therapy for the management of HER-2\/neu-overexpressing metastatic breast cancer","volume":"12","author":"Emens LA","year":"2005","unstructured":"Emens LA. Trastuzumab: Targeted therapy for the management of HER-2\/neu-overexpressing metastatic breast cancer. Am J Ther, 2005; 12(3):243\u2013253.","journal-title":"Am J Ther"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.4340.1"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw098"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871520615666150129211901"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm4012438"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602192940801"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.16174"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-005-0074-4"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-5-518"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/19368623.2022.2072504"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4411"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2014.02.008"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6792"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609054821"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30097-3"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.02.020"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2019.1616235"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12401"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-14-0077"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c12348"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197011)26:5<984::AID-CNCR2820260504>3.0.CO;2-E"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1159\/000524988"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1600220"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.344"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200510000-00002"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357909409038234"},{"issue":"7","key":"e_1_3_3_77_2","first-page":"2783","article-title":"Mafosfamide as a new anticancer agent: Preclinical investigations and clinical trials","volume":"32","author":"Mazur L","year":"2012","unstructured":"Mazur L, , Opydo-Chanek M, , Stojak M, et al. Mafosfamide as a new anticancer agent: Preclinical investigations and clinical trials. Anticancer Res, 2012; 32(7):2783\u20132789.","journal-title":"Anticancer Res"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-006-0112-x"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781003067634-10"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e328345e1e0"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijinfomgt.2020.102225"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118134"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.708943"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13051078"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2011.04.009"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188678"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.02.017"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1604535"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119912"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v9i1.2198"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad419"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32937"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2015.09.029"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911046"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-023-08809-3"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-18722-4_4"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.4028"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2020.100742"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.69424"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01296-5"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1186\/1897-4287-10-S4-A17"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.12.1811"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042288"},{"key":"e_1_3_3_104_2","unstructured":"Lambrechts Y Wildiers H Floris G et al. Dissection of molecular determinants of metastasis and detailed characterization of the age-related immunological profile in (older) patients with hormone-sensitive breast cancer. 2025."},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1177\/1758835919833519"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1032246"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601183340301"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2002.01540.x"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115239"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114643"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-020-00269-6"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.3390\/jox11040013"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16132478"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.02.003"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112375"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02998-6"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20209"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-024-03761-3"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008060720608"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1188\/04.ONF.E16-E23"},{"key":"e_1_3_3_121_2","first-page":"12","article-title":"Management of side effects from chemotherapy","author":"Kwok C","year":"2010","unstructured":"Kwok C. Management of side effects from chemotherapy. The Hongkong anti Cancer Society, 2010:12\u201316.","journal-title":"The Hongkong anti Cancer Society"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.9053"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-023-01954-6"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.14791\/btrt.2022.0018"},{"key":"e_1_3_3_125_2","article-title":"Side effects of chemotherapy and their management","author":"Appel E","year":"2023","unstructured":"Appel E. Side effects of chemotherapy and their management. Microreviews in Cell and Molecular Biology, 2023.","journal-title":"Microreviews in Cell and Molecular Biology"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1208\/ps020106"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-013-9419-7"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990493"},{"issue":"2","key":"e_1_3_3_129_2","first-page":"266","article-title":"Combination therapy strategies and advanced biomarkers can potentially enhance the precision-medicine treatment of metastatic breast cancer","volume":"15","author":"Lu B","year":"2024","unstructured":"Lu B, , Natarajan E. Combination therapy strategies and advanced biomarkers can potentially enhance the precision-medicine treatment of metastatic breast cancer. J Natural Sci, Biolo Med, 2024; 15(2):266.","journal-title":"J Natural Sci, Biolo Med"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S464245"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfss.2025.01.002"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.6.6.1357"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199958003-00001"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.07.006"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.01.007"}],"container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10849785251376173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10849785251376173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10849785251376173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:11:31Z","timestamp":1777385491000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10849785251376173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":134,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.1177\/10849785251376173"],"URL":"https:\/\/doi.org\/10.1177\/10849785251376173","relation":{},"ISSN":["1084-9785","1557-8852"],"issn-type":[{"value":"1084-9785","type":"print"},{"value":"1557-8852","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]}}}