{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:48:58Z","timestamp":1785840538033,"version":"3.56.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shapingba District Science and Health Joint Medical Research","award":["2023SQKWLH020"],"award-info":[{"award-number":["2023SQKWLH020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lactylation, a unique post-translational alteration, has been identified as an important epigenetic regulator of cancer metabolism, immune evasion, and treatment resistance. Recent research reveals that ultrasound-based biophysical stimulation may change tumor microenvironmental variables that affect lactate metabolism and subsequent lactylation processes. The purpose of this study was to better understand the predictive significance of lactylation-associated genes in lung adenocarcinoma (LUAD) and how they could interact with ultrasound-mediated treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Transcriptomic data from 867 LUAD samples were used to identify lactylation-related genes. Consensus clustering was used to separate LUAD cases into various lactylation subtypes. Differentially expressed genes were assessed for functional enrichment, mutation load, and immunological infiltration. A prognostic risk model was created using multivariate Cox regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Nineteen major lactylation-related genes divided patients with LUAD into three molecular subgroups with different clinical outcomes. A 10-gene prognostic model accurately predicted overall survival and was associated with stronger tumor stemness, increased mutational frequency, and decreased immunotherapy effectiveness in high-risk patients. Notably, computational predictions suggested that metabolic regulation might slow lactylation-driven tumor development, implying a synergistic treatment window.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Lactylation-associated gene profiles may serve as prognostic biomarkers and therapeutic modulators in LUAD. The combination of ultrasound-based therapies targeting lactylation pathways could be a viable technique for improving precision oncology and overcoming resistance mechanisms in lung cancer therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10849785251407489","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:53:06Z","timestamp":1767963186000},"page":"606-623","source":"Crossref","is-referenced-by-count":0,"title":["Lactylation Signatures as Predictors of Prognosis and Therapeutic Response in Lung Adenocarcinoma: Implications for Ultrasound-Based Therapeutic Strategies"],"prefix":"10.1177","volume":"41","author":[{"given":"Qingchun","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology, Chongqing University Cancer Hospital, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, Chongqing University Cancer Hospital, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, Chongqing University Cancer Hospital, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, Chongqing University Cancer Hospital, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, Chongqing University Cancer Hospital, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.04.028"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0406-2"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0259-8"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1678-1"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00710-w"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112033"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.3c00518"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph16050644"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.972020"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01523-1"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac558"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.034"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116982"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1384948"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216285"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1193"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216467"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.10.014"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.73398"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02308-z"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2274"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071640"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1052"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4329-7"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8224-x"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.1.240"},{"key":"e_1_3_8_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00608.x"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6621"},{"issue":"1","key":"e_1_3_8_32_2","first-page":"730380","article-title":"The Treg\/Th17 paradigm in lung cancer","volume":"2014","author":"Duan MC","year":"2014","unstructured":"Duan MC, , Zhong XN, , Liu GN, et al. 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