{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:36:55Z","timestamp":1788903415785,"version":"build-2803163510"},"reference-count":331,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Gastric cancer (GC) is among the most common malignancies worldwide and represents a major cause of cancer-related mortality. The incidence of GC varies significantly across regions due to genetic predisposition, environmental exposure, dietary habits, and infectious agents, particularly\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      . Despite its high prevalence, GC is often diagnosed at an advanced stage because of nonspecific or absent early clinical symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this review is to provide a comprehensive overview of the epidemiology, etiology, risk factors, molecular mechanisms, diagnostic biomarkers, and emerging therapeutic strategies for gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Relevant literature was reviewed to analyze the role of key molecular signaling pathways involved in gastric carcinogenesis, progression, metastasis, and therapeutic response. Current diagnostic tools, biomarkers, and treatment approaches\u2014including conventional therapies, alternative systems of medicine, nanotechnology-based interventions, and ongoing clinical research\u2014were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Recent molecular classifications have highlighted the critical involvement of signaling pathways such as EGFR\/HER2, p53, PI3K, and related pathways in GC development and progression. The identification of biomarkers, including circulating tumor cells and ribonucleic acids, has improved diagnostic accuracy. Advances in targeted therapy and nanotechnology-based drug delivery systems have demonstrated potential in enhancing treatment efficacy and reducing adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Gastric cancer remains a serious global health concern with limited survival outcomes despite advances in treatment. Improved understanding of molecular signaling pathways and biomarker-based diagnostics offers promising opportunities for early detection and targeted therapy. Continued research into innovative preventive and therapeutic approaches is essential for patients with gastric cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10849785251408598","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T17:18:25Z","timestamp":1767028705000},"page":"359-389","source":"Crossref","is-referenced-by-count":2,"title":["Advances in Gastric Cancer Management: Signaling Pathways, Emerging Diagnostic and Therapeutic Strategies"],"prefix":"10.1177","volume":"41","author":[{"given":"Rutvi","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Chandigarh University, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Jurel","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research, GLA University, Mathura, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-7412","authenticated-orcid":false,"given":"Akash","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupendra G.","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Parul Institute of Pharmacy, Faculty of Pharmacy, Parul University, Waghodia, Vadodara, India."},{"name":"Centre for Research Impact &amp; Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-2830","authenticated-orcid":false,"given":"Sumel","family":"Ashique","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Bharat Technology, Uluberia, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.901559"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.92988"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.70048"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.108557"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116257"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117100"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2014-x"},{"key":"e_1_3_4_9_2","volume-title":"Stomach (Gastric) Cancer Prevention (PDQ\u00ae)","author":"Screening P","year":"2024","unstructured":"Screening P, , Board PE. Stomach (Gastric) Cancer Prevention (PDQ\u00ae). PDQ Cancer Information Summaries [Internet]: National Cancer Institute (US); 2024."},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.36922\/arnm.8350"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168638"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116251"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-024-00518-6"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2022.122000"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48307-z"},{"issue":"3","key":"e_1_3_4_16_2","first-page":"251","article-title":"Gastric cancer: Classification, histology and application of molecular pathology","volume":"3","author":"Hu B","year":"2012","unstructured":"Hu B, , El Hajj N, , Sittler S, et al. Gastric cancer: Classification, histology and application of molecular pathology. J Gastrointest Oncol, 2012; 3(3):251\u2013261.","journal-title":"J Gastrointest Oncol"},{"issue":"7","key":"e_1_3_4_17_2","first-page":"486","article-title":"Clinicopathologic features of gastric adenocarcinoma based on the revised Lauren\u2019s classification","volume":"47","author":"Li Y","year":"2018","unstructured":"Li Y, , Xue XW, , Luo YF, et al. Clinicopathologic features of gastric adenocarcinoma based on the revised Lauren\u2019s classification. Zhonghua Bing Li Xue Za Zhi, 2018; 47(7):486\u2013491.","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-823"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00300-6"},{"issue":"5","key":"e_1_3_4_20_2","first-page":"4347","article-title":"Diagnostic value of urinary molecular markers in bladder cancer","volume":"23","author":"Eissa S","year":"2003","unstructured":"Eissa S, , Swellam M, , el-Mosallamy H, et al. Diagnostic value of urinary molecular markers in bladder cancer. Anticancer Res, 2003; 23(5b):4347\u20134355.","journal-title":"Anticancer Res"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1226652"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09925-3"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S149619"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29122850"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115927"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30835"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-19104-6"},{"key":"e_1_3_4_28_2","article-title":"WHO classification of tumours of the digestive system","author":"Cancer IAfRo","year":"2019","unstructured":"Cancer IAfRo. WHO classification of tumours of the digestive system. IntAgency for Res on Cancer, 2019.","journal-title":"IntAgency for Res on Cancer"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.023"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg486"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30219-9"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2021.101730"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-73823-9"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600663"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.6.758"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114012"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116618"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199806000-00001"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2012.1701"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4123420"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1897-4287-10-18"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7302.1566\/c"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32707"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24445"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-67"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000290"},{"issue":"19","key":"e_1_3_4_48_2","first-page":"4823","article-title":"High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL\/6 mice","volume":"59","author":"Fox JG","year":"1999","unstructured":"Fox JG, , Dangler CA, , Taylor NS, et al. High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL\/6 mice. Cancer Res, 1999; 59(19):4823\u20134828.","journal-title":"Cancer Res"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2005.00006.x"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu082"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2021.03.001"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006573"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2017.06.002"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.149"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep04202"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.007302-0"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000542"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.08.013"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103429"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01185-7"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02815-4"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/15330338241271935"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01190-w"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.644788"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-858638"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i45.6577"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2006.06.007"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199806)20:6<473::AID-BIES5>3.0.CO;2-N"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-50"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3804"},{"issue":"1","key":"e_1_3_4_71_2","first-page":"89","article-title":"Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K\/AKT pathway","volume":"24","author":"Wen YG","year":"2010","unstructured":"Wen YG, , Wang Q, , Zhou CZ, et al. Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K\/AKT pathway. Oncol Rep, 2010; 24(1):89\u201395.","journal-title":"Oncol Rep"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i2.192"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i38.13804"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0142-z"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11051312"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e09309"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.12.002"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omton.2024.200857"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0074-8"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.12.009"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(09)02001-6"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206749"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.5858\/2002-126-1096-RGMAEO"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i5.623"},{"issue":"1","key":"e_1_3_4_85_2","first-page":"116","article-title":"Prognostic significance of aberrant gene methylation in gastric cancer","volume":"2","author":"Shi J","year":"2012","unstructured":"Shi J, , Zhang G, , Yao D, et al. Prognostic significance of aberrant gene methylation in gastric cancer. Am J Cancer Res, 2012; 2(1):116\u2013129.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3074"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602854"},{"key":"e_1_3_4_88_2","first-page":"645","article-title":"The tumor suppressor RASSF1A in human carcinogenesis: An update","volume":"20","author":"Dammann R","year":"2005","unstructured":"Dammann R, , Schagdarsurengin U, , Seidel C, et al. The tumor suppressor RASSF1A in human carcinogenesis: An update. Histol Histopathol, 2005; 20:645\u2013663.","journal-title":"Histol Histopathol"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.111007"},{"issue":"4","key":"e_1_3_4_90_2","first-page":"2727","article-title":"Expression of epidermal growth factor receptor family proteins (EGFR, c-erbB-2 and c-erbB-3) in gastric cancer and chronic gastritis","volume":"18","author":"Slesak B","year":"1998","unstructured":"Slesak B, , Harlozinska A, , Porebska I, et al. Expression of epidermal growth factor receptor family proteins (EGFR, c-erbB-2 and c-erbB-3) in gastric cancer and chronic gastritis. Anticancer Res, 1998; 18(4A):2727\u20132732.","journal-title":"Anticancer Res"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2005.apm_284.x"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi064"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2866"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2132"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10180"},{"issue":"4","key":"e_1_3_4_96_2","first-page":"439","article-title":"Genetic alterations in gastric precancerous lesions","volume":"21","author":"Karaman A","year":"2010","unstructured":"Karaman A, , Kabalar ME, , Binici DN, et al. Genetic alterations in gastric precancerous lesions. Genet Couns, 2010; 21(4):439\u2013450.","journal-title":"Genet Couns"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0464-y"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.150186"},{"issue":"84","key":"e_1_3_4_99_2","first-page":"1126","article-title":"Wnt pathway is involved in advanced gastric carcinoma","volume":"55","author":"Zhang H","year":"2008","unstructured":"Zhang H, , Xue Y. Wnt pathway is involved in advanced gastric carcinoma. Hepatogastroenterology, 2008; 55(84):1126\u20131130.","journal-title":"Hepatogastroenterology"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.1570"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2359"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.4318\/tjg.2010.0092"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00782.x"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.11.008"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8281-1"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00136-8"},{"issue":"3","key":"e_1_3_4_107_2","first-page":"172","article-title":"Gastric cancer carcinogenesis and tumor progression","volume":"83","author":"Corso G","year":"2012","unstructured":"Corso G, , Seruca R, , Roviello F. Gastric cancer carcinogenesis and tumor progression. Ann Ital Chir, 2012; 83(3):172\u2013176.","journal-title":"Ann Ital Chir"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.07.045"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i18.2568"},{"issue":"3","key":"e_1_3_4_110_2","first-page":"177","article-title":"Familial gastric cancer and germline mutations of E-cadherin","volume":"83","author":"Corso G","year":"2012","unstructured":"Corso G, , Marrelli D, , Roviello F. Familial gastric cancer and germline mutations of E-cadherin. Ann Ital Chir, 2012; 83(3):177\u2013182.","journal-title":"Ann Ital Chir"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i8.1182"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.labinv.2023.100078"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203286"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i2.250"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i7.1421"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01258.x"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003505200"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0733"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2010.11.005"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.07.014"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12083"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90506-5"},{"key":"e_1_3_4_123_2","first-page":"4136","article-title":"Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue","volume":"7","author":"Sasaki N","year":"2001","unstructured":"Sasaki N, , Morisaki T, , Hashizume K, et al. Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 2001; 7:4136\u20134142.","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"2","key":"e_1_3_4_124_2","first-page":"1071","article-title":"Nuclear factor-kappaB p65 is a prognostic indicator in gastric carcinoma","volume":"24","author":"Yamanaka N","year":"2004","unstructured":"Yamanaka N, , Sasaki N, , Tasaki A, et al. Nuclear factor-kappaB p65 is a prognostic indicator in gastric carcinoma. Anticancer Res, 2004; 24(2C):1071\u20131075.","journal-title":"Anticancer Res"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122916"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114058"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121997"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061899"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.617677"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117045"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-016-0783-3"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03012-z"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0134-x"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2024.06.004"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-1031"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05320-8"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2189295"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1016817"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107406"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01336-x"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/4123737"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-016-0623-3"},{"key":"e_1_3_4_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102923"},{"key":"e_1_3_4_144_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-017-0012-4"},{"key":"e_1_3_4_145_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.17.12928"},{"key":"e_1_3_4_146_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1353-3"},{"key":"e_1_3_4_147_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01168-8"},{"key":"e_1_3_4_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.100936"},{"key":"e_1_3_4_149_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01460-1"},{"key":"e_1_3_4_150_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3942-9"},{"key":"e_1_3_4_151_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12121862"},{"key":"e_1_3_4_152_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-008-9166-3"},{"key":"e_1_3_4_153_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05965-z"},{"key":"e_1_3_4_154_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108647"},{"key":"e_1_3_4_155_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19883-1"},{"key":"e_1_3_4_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2018.09.002"},{"key":"e_1_3_4_157_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.856591"},{"key":"e_1_3_4_158_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.744839"},{"key":"e_1_3_4_159_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201801660"},{"key":"e_1_3_4_160_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA01947C"},{"key":"e_1_3_4_161_2","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.201700368"},{"key":"e_1_3_4_162_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC03751E"},{"key":"e_1_3_4_163_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.07.007"},{"issue":"1","key":"e_1_3_4_164_2","first-page":"47","article-title":"Application of novel targeting nanoparticles contrast agent combined with contrast-enhanced computed tomography during screening for early-phase gastric carcinoma","volume":"15","author":"Zhang K","year":"2018","unstructured":"Zhang K, , Du X, , Yu K, et al. Application of novel targeting nanoparticles contrast agent combined with contrast-enhanced computed tomography during screening for early-phase gastric carcinoma. Exp Ther Med, 2018; 15(1):47\u201354.","journal-title":"Exp Ther Med"},{"key":"e_1_3_4_165_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S62837"},{"key":"e_1_3_4_166_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08092-w"},{"key":"e_1_3_4_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2018.12.002"},{"key":"e_1_3_4_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.01.006"},{"key":"e_1_3_4_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2020.05.019"},{"key":"e_1_3_4_170_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i19.5672"},{"key":"e_1_3_4_171_2","doi-asserted-by":"publisher","DOI":"10.1159\/000481404"},{"key":"e_1_3_4_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2024.04.026"},{"key":"e_1_3_4_173_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.5908"},{"key":"e_1_3_4_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2019.06.005"},{"key":"e_1_3_4_175_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19961101)78:9<1988::AID-CNCR21>3.0.CO;2-T"},{"key":"e_1_3_4_176_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.1.261"},{"issue":"18","key":"e_1_3_4_177_2","article-title":"Capecitabine and oxaliplatin for advanced esophagogastric cancer","volume":"358","author":"B\u00f6lke E","year":"2008","unstructured":"B\u00f6lke E, , Peiper M, , Budach W. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med, 2008; 358(18):1965; author reply 1965.","journal-title":"N Engl J Med"},{"key":"e_1_3_4_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32557-1"},{"issue":"12","key":"e_1_3_4_179_2","first-page":"7037","article-title":"FOLFOX as first-line therapy for gastric cancer with severe peritoneal metastasis","volume":"37","author":"Masuishi T","year":"2017","unstructured":"Masuishi T, , Kadowaki S, , Kondo M, et al. FOLFOX as first-line therapy for gastric cancer with severe peritoneal metastasis. Anticancer Res, 2017; 37(12):7037\u20137042.","journal-title":"Anticancer Res"},{"key":"e_1_3_4_180_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9632"},{"key":"e_1_3_4_181_2","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2024.2416985"},{"key":"e_1_3_4_182_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052122"},{"key":"e_1_3_4_183_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004413"},{"key":"e_1_3_4_184_2","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2069883"},{"key":"e_1_3_4_185_2","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12214"},{"key":"e_1_3_4_186_2","volume-title":"Overall Survival from the Phase 3 POLO Trial: Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer","author":"Golan T","year":"2021","unstructured":"Golan T, , Hammel P, , Reni M, et al. Overall Survival from the Phase 3 POLO Trial: Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. American Society of Clinical Oncology; 2021."},{"key":"e_1_3_4_187_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199908000-00005"},{"key":"e_1_3_4_188_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.21"},{"key":"e_1_3_4_189_2","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000171"},{"key":"e_1_3_4_190_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3898"},{"key":"e_1_3_4_191_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61719-5"},{"key":"e_1_3_4_192_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0903-9"},{"key":"e_1_3_4_193_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.5995"},{"key":"e_1_3_4_194_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03296"},{"key":"e_1_3_4_195_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30271-0"},{"key":"e_1_3_4_196_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx107"},{"key":"e_1_3_4_197_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.3_suppl.160"},{"key":"e_1_3_4_198_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01800-8"},{"key":"e_1_3_4_199_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.0018"},{"key":"e_1_3_4_200_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211358"},{"key":"e_1_3_4_201_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-019-01034-7"},{"key":"e_1_3_4_202_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.3370"},{"key":"e_1_3_4_203_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00797-2"},{"key":"e_1_3_4_204_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109970"},{"key":"e_1_3_4_205_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0132-0"},{"key":"e_1_3_4_206_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00226-1"},{"key":"e_1_3_4_207_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111663"},{"key":"e_1_3_4_208_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-007-9192-0"},{"key":"e_1_3_4_209_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7270.2005.00077.x"},{"key":"e_1_3_4_210_2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.9.9.11431"},{"key":"e_1_3_4_211_2","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.23418"},{"key":"e_1_3_4_212_2","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.571"},{"key":"e_1_3_4_213_2","doi-asserted-by":"publisher","DOI":"10.1159\/000488571"},{"key":"e_1_3_4_214_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174631"},{"issue":"11","key":"e_1_3_4_215_2","first-page":"2212","article-title":"miR-485-5p acts as a negative regulator in gastric cancer progression by targeting flotillin-1","volume":"7","author":"Kang M","year":"2015","unstructured":"Kang M, , Ren MP, , Zhao L, et al. miR-485-5p acts as a negative regulator in gastric cancer progression by targeting flotillin-1. Am J Transl Res, 2015; 7(11):2212\u20132222.","journal-title":"Am J Transl Res"},{"key":"e_1_3_4_216_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0587-8"},{"key":"e_1_3_4_217_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.55381"},{"key":"e_1_3_4_218_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-021-01312-y"},{"key":"e_1_3_4_219_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.03.018"},{"key":"e_1_3_4_220_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117809"},{"key":"e_1_3_4_221_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7305"},{"key":"e_1_3_4_222_2","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2004.11732673"},{"issue":"4","key":"e_1_3_4_223_2","first-page":"601","article-title":"Reversal of multidrug resistance of gastric cancer cells by downregulation of Akt1 with Akt1 siRNA","volume":"25","author":"Han Z","year":"2006","unstructured":"Han Z, , Hong L, , Wu K, et al. Reversal of multidrug resistance of gastric cancer cells by downregulation of Akt1 with Akt1 siRNA. J Exp Clin Cancer Res, 2006; 25(4):601\u2013606.","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_3_4_224_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17526"},{"issue":"11","key":"e_1_3_4_225_2","first-page":"2397","article-title":"Effects of siRNA-mediated silencing of myeloid cell leukelia-1 on the biological behaviors and drug resistance of gastric cancer cells","volume":"7","author":"Li BP","year":"2015","unstructured":"Li BP, , Liu JL, , Chen JQ, et al. Effects of siRNA-mediated silencing of myeloid cell leukelia-1 on the biological behaviors and drug resistance of gastric cancer cells. Am J Transl Res, 2015; 7(11):2397\u20132411.","journal-title":"Am J Transl Res"},{"key":"e_1_3_4_226_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026401"},{"key":"e_1_3_4_227_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-1736-3"},{"key":"e_1_3_4_228_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1204-2"},{"issue":"3","key":"e_1_3_4_229_2","first-page":"497","article-title":"Down-regulation of \u03b2-1,3-N-acetylglucosaminyltransferase-8 by siRNA inhibits the growth of human gastric cancer","volume":"4","author":"Liu Z","year":"2011","unstructured":"Liu Z, , Shen L, , Xu L, et al. Down-regulation of \u03b2-1,3-N-acetylglucosaminyltransferase-8 by siRNA inhibits the growth of human gastric cancer. Mol Med Rep, 2011; 4(3):497\u2013503.","journal-title":"Mol Med Rep"},{"key":"e_1_3_4_230_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010236"},{"issue":"2","key":"e_1_3_4_231_2","first-page":"122","article-title":"Inhibitory effect of siRNA-Annexin A7 on growth, migration, and invasion in BGC823 cells and gastric cancer xenograftsin nude mice","volume":"13","author":"Yuan HF","year":"2020","unstructured":"Yuan HF, , Li Y, , Tan BB, et al. Inhibitory effect of siRNA-Annexin A7 on growth, migration, and invasion in BGC823 cells and gastric cancer xenograftsin nude mice. Int J Clin Exp Pathol, 2020; 13(2):122\u2013131.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_4_232_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3135"},{"key":"e_1_3_4_233_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7701122"},{"key":"e_1_3_4_234_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00558D"},{"key":"e_1_3_4_235_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.587997"},{"key":"e_1_3_4_236_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00292"},{"key":"e_1_3_4_237_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14040844"},{"key":"e_1_3_4_238_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050673"},{"key":"e_1_3_4_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.09.032"},{"key":"e_1_3_4_240_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124345"},{"key":"e_1_3_4_241_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116486"},{"key":"e_1_3_4_242_2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.4.2591"},{"key":"e_1_3_4_243_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122850"},{"key":"e_1_3_4_244_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e30803"},{"key":"e_1_3_4_245_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138706"},{"key":"e_1_3_4_246_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.112022"},{"key":"e_1_3_4_247_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2023.04.016"},{"key":"e_1_3_4_248_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.05.018"},{"key":"e_1_3_4_249_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.11.019"},{"key":"e_1_3_4_250_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111603"},{"key":"e_1_3_4_251_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S386037"},{"key":"e_1_3_4_252_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2003.12.015"},{"key":"e_1_3_4_253_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.04.042"},{"key":"e_1_3_4_254_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b17363"},{"key":"e_1_3_4_255_2","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2011.5318"},{"key":"e_1_3_4_256_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1nr10586h"},{"key":"e_1_3_4_257_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119580"},{"key":"e_1_3_4_258_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.33266"},{"key":"e_1_3_4_259_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i25.3851"},{"key":"e_1_3_4_260_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111109"},{"key":"e_1_3_4_261_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00029B"},{"issue":"10","key":"e_1_3_4_262_2","first-page":"883","article-title":"Novel therapeutic strategy for human epidermal growth factor receptor 2-positive gastric cancer","volume":"44","author":"Kanaya N","year":"2017","unstructured":"Kanaya N, , Kuroda S, , Kubota T, et al. Novel therapeutic strategy for human epidermal growth factor receptor 2-positive gastric cancer. Gan To Kagaku Ryoho, 2017; 44(10):883\u2013885.","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_3_4_263_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2023.11.006"},{"key":"e_1_3_4_264_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154608"},{"key":"e_1_3_4_265_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15132830"},{"key":"e_1_3_4_266_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105384"},{"key":"e_1_3_4_267_2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.16.6791"},{"key":"e_1_3_4_268_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105734"},{"key":"e_1_3_4_269_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15932"},{"key":"e_1_3_4_270_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2022.5375"},{"key":"e_1_3_4_271_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.902711"},{"key":"e_1_3_4_272_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108314"},{"key":"e_1_3_4_273_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2893"},{"key":"e_1_3_4_274_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2383"},{"key":"e_1_3_4_275_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109430"},{"key":"e_1_3_4_276_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2625"},{"key":"e_1_3_4_277_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061350"},{"key":"e_1_3_4_278_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e28672"},{"key":"e_1_3_4_279_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2023.11.001"},{"key":"e_1_3_4_280_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(22)60154-7"},{"key":"e_1_3_4_281_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2022.02.006"},{"key":"e_1_3_4_282_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2024.100881"},{"key":"e_1_3_4_283_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112245"},{"key":"e_1_3_4_284_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155169"},{"key":"e_1_3_4_285_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118277"},{"key":"e_1_3_4_286_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.04.037"},{"key":"e_1_3_4_287_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117013"},{"key":"e_1_3_4_288_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.116842"},{"key":"e_1_3_4_289_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116674"},{"key":"e_1_3_4_290_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117791"},{"key":"e_1_3_4_291_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.101021"},{"key":"e_1_3_4_292_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17393"},{"key":"e_1_3_4_293_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e28833"},{"key":"e_1_3_4_294_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071600"},{"key":"e_1_3_4_295_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116310"},{"key":"e_1_3_4_296_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093233"},{"key":"e_1_3_4_297_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21650"},{"key":"e_1_3_4_298_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_3_4_299_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00462-0"},{"key":"e_1_3_4_300_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"e_1_3_4_301_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01258-7"},{"key":"e_1_3_4_302_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S329208"},{"key":"e_1_3_4_303_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03579-x"},{"key":"e_1_3_4_304_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060310-170328"},{"key":"e_1_3_4_305_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0107-0"},{"key":"e_1_3_4_306_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10959"},{"key":"e_1_3_4_307_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.679806"},{"key":"e_1_3_4_308_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0972-8"},{"key":"e_1_3_4_309_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155220"},{"key":"e_1_3_4_310_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27692"},{"key":"e_1_3_4_311_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0713-x"},{"key":"e_1_3_4_312_2","first-page":"359","article-title":"Development of an MRI-visible nonviral vector for siRNA delivery targeting gastric cancer","volume":"7","author":"Chen Y","year":"2012","unstructured":"Chen Y, , Wang W, , Lian G, et al. Development of an MRI-visible nonviral vector for siRNA delivery targeting gastric cancer. Int J Nanomedicine, 2012; 7:359\u2013368.","journal-title":"Int J Nanomedicine"},{"key":"e_1_3_4_313_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.032"},{"key":"e_1_3_4_314_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201200650"},{"key":"e_1_3_4_315_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.10.032"},{"key":"e_1_3_4_316_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.10.045"},{"key":"e_1_3_4_317_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp5002747"},{"key":"e_1_3_4_318_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01544"},{"issue":"5","key":"e_1_3_4_319_2","first-page":"8079","article-title":"Target-specific delivery of oxaliplatin to HER2-positive gastric cancer cells in\u00a0vivo using oxaliplatin-au-fe3o4-herceptin nanoparticles","volume":"15","author":"Liu D","year":"2018","unstructured":"Liu D, , Li X, , Chen C, et al. Target-specific delivery of oxaliplatin to HER2-positive gastric cancer cells in\u00a0vivo using oxaliplatin-au-fe3o4-herceptin nanoparticles. Oncol Lett, 2018; 15(5):8079\u20138087.","journal-title":"Oncol Lett"},{"key":"e_1_3_4_320_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppsc.201900015"},{"key":"e_1_3_4_321_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S26697"},{"key":"e_1_3_4_322_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.12.002"},{"key":"e_1_3_4_323_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.01.006"},{"key":"e_1_3_4_324_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR03003F"},{"key":"e_1_3_4_325_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vacune.2024.02.012"},{"key":"e_1_3_4_326_2","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1894"},{"key":"e_1_3_4_327_2","doi-asserted-by":"publisher","DOI":"10.3390\/v15030668"},{"key":"e_1_3_4_328_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115361"},{"key":"e_1_3_4_329_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114973"},{"key":"e_1_3_4_330_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020622"},{"key":"e_1_3_4_331_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.827506"},{"key":"e_1_3_4_332_2","unstructured":"Gastric Cancer. US Government 2024."}],"container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10849785251408598","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10849785251408598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10849785251408598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T12:20:31Z","timestamp":1780748431000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10849785251408598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":331,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1177\/10849785251408598"],"URL":"https:\/\/doi.org\/10.1177\/10849785251408598","relation":{},"ISSN":["1084-9785","1557-8852"],"issn-type":[{"value":"1084-9785","type":"print"},{"value":"1557-8852","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]}}}