{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:19:10Z","timestamp":1787933950798,"version":"build-2784847793"},"reference-count":47,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cyclooxygenase-2 (COX-2) serves as a pivotal molecule bridging inflammation and tumor development, playing a central role in the initiation, progression, and malignant transformation of colorectal adenomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This review systematically examines COX-2 expression patterns, molecular regulatory networks, and its potential applications in clinical diagnosis, prognosis assessment, and chemoprevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Evidence indicates that COX-2 exhibits significantly elevated expression in adenoma tissues (e.g., 54.8% positive rate in polyps vs. 18.5% in adjacent tissue), driving pathological progression through multiple mechanisms including cell proliferation induction, apoptosis inhibition, angiogenesis promotion, and tumor immune microenvironment remodeling. Nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors have demonstrated clear promise in adenoma chemoprevention (with agents such as celecoxib reducing advanced adenoma recurrence risk by 33%\u221245%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>COX-2 is a critical early-event biomarker and therapeutic target in colorectal adenomas. Targeting the COX-2 pathway represents a viable strategy for prevention, although challenges regarding safety and personalized application remain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10849785261415777","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:51:08Z","timestamp":1769169068000},"page":"655-663","source":"Crossref","is-referenced-by-count":0,"title":["Research Progress of Cyclooxygenase-2 in Colorectal Adenomas"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0418-805X","authenticated-orcid":false,"given":"Zhongsen","family":"Dou","sequence":"first","affiliation":[{"name":"Wannan Medical College, Wuhu City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Wannan Medical College, Wuhu City, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanglai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Anqing First People\u2019s Hospital, Anqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327736"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914589117"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1185-3109"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2741\/4914"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph15121471"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-021-03880-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2020.02.007"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2014.47907"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM118.006295"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10426"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/384644a0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910701"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11519"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i48.5454"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043453171"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/2516865720986231"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246254"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327323"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-21-0572"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255235"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13030699"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.57594"},{"issue":"4","key":"e_1_3_3_26_2","first-page":"1219","article-title":"Atorvastatin inhibits proliferation and promotes apoptosis of colon cancer cells via COX-2\/PGE2\/\u03b2-Catenin Pathway","volume":"26","author":"Cai S","year":"2021","unstructured":"Cai S, , Gao Z. 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