{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:48:33Z","timestamp":1785840513252,"version":"3.56.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the clinical impact of docetaxel and capecitabine administered under ultrasound-mediated enhancement in patients with advanced triple-negative breast cancer (TNBC), with an emphasis on safety, quality of life, immunological modulation, and therapeutic efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 80 patients with advanced TNBC who received treatment at this institution between October 2021 and October 2022 were chosen at random and placed in either the control group (CG,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 40) or the observation group (OG,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 40). While the OG received capecitabine and docetaxel supplemented by an ultrasound-mediated drug delivery strategy intended to enhance intratumoral absorption, the CG received cisplatin and docetaxel. The groups were compared in terms of clinical response, immunological function, quality of life (FACT-B), incidence of adverse events, and serum tumor markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with the CG, the OG showed a considerably greater response rate (RR) and disease control rate (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). Immunoglobulin (Ig)G, IgM, and IgA levels in the CG dramatically decreased after two treatment cycles (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05), while levels in the OG were maintained and continued to be greater than those in the CG (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). Both groups\u2019 FACT-B scores dropped (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05), but the OG\u2019s reduction was less noticeable (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05), suggesting that ultrasound-enhanced therapy improved quality-of-life preservation. The OG had decreased incidence of adverse events; however, this difference was not statistically significant (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05). Following therapy, tumor markers CA125 and CA153 reduced in both cohorts (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05), with the OG showing larger reductions (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Capecitabine and docetaxel administered via ultrasound improve therapeutic efficacy in advanced TNBC, lessen immune suppression brought on by treatment, improve quality of life, and support a positive safety profile while encouraging higher decreases in tumor marker expression. These results demonstrate the potential therapeutic benefit of using ultrasound-based medication delivery techniques into TNBC systemic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10849785261420926","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T10:09:58Z","timestamp":1770372598000},"page":"559-564","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Efficacy of Capecitabine and Docetaxel Efficacy in Advanced Triple-Negative Breast Cancer Along with Ultrasound-Mediated Drug Delivery"],"prefix":"10.1177","volume":"41","author":[{"given":"Dongbo","family":"Liu","sequence":"first","affiliation":[{"name":"Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, Jiangsu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Liu","sequence":"additional","affiliation":[{"name":"Suzhou Hospital, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Suzhou, Jiangsu, China."},{"name":"Suzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, Jiangsu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chang","sequence":"additional","affiliation":[{"name":"Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, Jiangsu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Fifth People\u2019s Hospital of Suzhou\/The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01296-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042420-093238"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00565-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.06.005"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5135"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31704-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.02474"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.73152"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612645"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23370"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2008.n.017"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04167-y"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108253"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/ppo.0000000000000500"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202809"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02332-1"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188481"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.08.001"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1914609"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.01.005"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.6120"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-018-1845-0"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i5.1745"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-020-01058-3"}],"container-title":["Cancer 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