{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:54Z","timestamp":1792787694871,"version":"4.5.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Natural Science Foundation of Tianjin","award":["23JCZDJC00290"],"award-info":[{"award-number":["23JCZDJC00290"]}]},{"name":"Science Foundation for Distinguished Young Scholars of Tianjin","award":["24JCJQJC00080"],"award-info":[{"award-number":["24JCJQJC00080"]}]},{"name":"Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2021-RC310-010"],"award-info":[{"award-number":["2021-RC310-010"]}],"id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2024-JKCS-24"],"award-info":[{"award-number":["2024-JKCS-24"]}],"id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">\n                      <jats:bold>Purpose:<\/jats:bold>\n                    <\/jats:italic>\n                    Targeted radionuclide therapy with\n                    <jats:sup>177<\/jats:sup>\n                    Lu-PSMA-617 prolongs radiographical progression-free survival in prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC), yet 13% of patients develop symptomatic skeletal events. The authors hypothesized that hemoglobin-based oxygen carriers (HBOCs) could potentiate\n                    <jats:sup>177<\/jats:sup>\n                    Lu-PSMA-617 by reprogramming bone marrow (BM) immunity.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Using PSMA-expressing xenografts, they demonstrated that concomitant HBOC administration significantly reduced tumor volume without increasing systemic toxicity. To dissect the underlying mechanism, the authors performed high-resolution single-cell RNA sequencing of murine BM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>\n                      HBOC treatment markedly expanded mature neutrophils, plasmacytoid dendritic cells, classical monocytes, natural killer T cells, and mature B cells, while concomitantly upregulating DNA damage repair genes such as\n                      <jats:italic toggle=\"yes\">Parp9<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Dtx3l<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Smchd1<\/jats:italic>\n                      within these subsets. Gene set enrichment analysis confirmed significant activation of DNA damage response pathways, implying enhanced cellular radioresistance and improved tolerance to \u03b2-particle irradiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>\n                      Thus, HBOCs improve\n                      <jats:sup>177<\/jats:sup>\n                      Lu-PSMA-617 antitumor efficacy indirectly via immune-subset expansion and DNA-repair reinforcement, offering a clinically feasible and safe strategy to optimize combination protocols for patients with mCRPC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10849785261448523","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:32:08Z","timestamp":1779442328000},"page":"794-810","source":"Crossref","is-referenced-by-count":0,"title":["Hemoglobin-Based Oxygen Carriers Promoted the Antitumor Effect of\n                    <sup>177<\/sup>\n                    Lu-PSMA-617 by Enhancing DNA Repair Capacity of Immune Cells"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3711-2425","authenticated-orcid":false,"given":"Danyue","family":"Qu","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Shao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Radiation 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