{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:19:10Z","timestamp":1787933950762,"version":"build-2784847793"},"reference-count":28,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Biotherapy and Radiopharmaceuticals"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Metastatic castration-resistant prostate cancer (mCRPC) remains a therapeutic challenge, particularly in patients with suboptimal response to\n                      <jats:sup>177<\/jats:sup>\n                      Lu-PSMA-617. Terbium-161 (Tb-161), with its emission of \u03b2-particles and high-LET Auger\/conversion electrons, offers potential advantages in targeting micrometastases. However, clinical validation, especially in resource-limited settings, remains limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This single-center, proof-of-concept study was conducted at the Department of Nuclear Medicine, FMRI, Gurgaon. Manual in-house radiolabeling of PSMA-617 with Tb-161 was performed. The samples were withdrawn for quality control analyses. Five mCRPC patients were administered Tb-161 PSMA-617. Post-therapy planar and single-photon emission computed tomography\/computed tomography (SPECT\/CT) imaging was conducted to assess biodistribution and dosimetric analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Radiolabeling PSMA-617 with Tb-161 was more than 95% efficient with 55 min of heating at 95\u00b0C. The radiochemical purity was &gt;98% for all the runs (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5). The sample was found to be sterile with no gel formation seen after 15 d for all the batches. Post-therapy imaging demonstrated favorable biodistribution and high tumor uptake. Dosimetric analysis revealed absorbed doses comparable or superior to historical\n                      <jats:sup>177<\/jats:sup>\n                      Lu-PSMA-617 data. No acute adverse events or safety concerns were observed post administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study successfully demonstrates the feasibility of manual in-house synthesis and clinical application of Tb-161 PSMA-617 in an Indian tertiary care setting. The favorable synthesis, imaging, biodistribution, and dosimetric profile support its potential as a next-generation theranostic agent for mCRPC. These findings warrant further validation through larger, controlled clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10849785261454146","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T05:50:16Z","timestamp":1779861016000},"page":"721-732","source":"Crossref","is-referenced-by-count":0,"title":["Validation of Manual In-House Synthesis, Imaging, Biodistribution, and Dosimetry of Tb-161 PSMA-617 for mCRPC Patients in a Tertiary Health Care Center: A Proof-of-Concept Study"],"prefix":"10.1177","volume":"41","author":[{"given":"Parul","family":"Thakral","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Uppal","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinalini","family":"Koley","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan","family":"Thakrani","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmender","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5883-0865","authenticated-orcid":false,"given":"Ishita","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.07.005"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107322"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00237-3"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-020-00301-2"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41181-019-0063-6"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2011.02.007"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.170423"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092011"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2798-3"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2563-z"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04345-0"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-023-00589-w"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000004589"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00332-8"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.267650"},{"key":"e_1_3_2_17_1","first-page":"37S","article-title":"MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates","volume":"40","author":"Siegel JA","year":"1999","unstructured":"16.Siegel JA, , Thomas SR, , Stubbs JB, et al. MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates. J Nucl Med 1999;40:37S\u201361S.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2011.0012"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.92273"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-024-00611-9"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.258376"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.265291"},{"key":"e_1_3_2_23_1","volume-title":"NCI Common Terminology Criteria for Adverse Events (CTCAE) Data Fles and Related Documents","author":"National Cancer Institute","year":"2018","unstructured":"22.National Cancer Institute. NCI Common Terminology Criteria for Adverse Events (CTCAE) Data Fles and Related Documents. 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