{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:11:34Z","timestamp":1787019094800,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,4,21]],"date-time":"2010-04-21T00:00:00Z","timestamp":1271808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Atten Disord"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>Objective: This trial evaluated the effect of methylphenidate transdermal system (MTS) on the full spectrum of adult symptoms (attention-disorganization, hyperactivity-impulsivity, emotional dysregulation [ED], and oppositional-defiant disorder [ODD]) found in this disorder. Method: This placebo-controlled, double-blind, flexible-dose, crossover trial employed the Wender\u2014Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) and Connor\u2019s Adult ADHD Rating Scale (CAARS) and two measures of adult ODD. Treatment responses of all participants and four subgroups (ADHDalone, ADHD + ED, ADHD + ODD, and ADHD + ED + ODD) were assessed. Results: Around 23% of baseline participants were ADHD alone, 31% were ADHD + ED, 10% were ADHD + ODD, and 36% were ADHD + ED + ODD. There was a significant treatment effect for all symptom areas and all four subgroups. MTS was associated with significantly more adverse events, especially dermatologic side effects. Conclusions: MTS was effective in treating adult ADHD. This clinical trial included numerous participants meeting criteria for ED and ODD. All ADHD symptoms responded positively to treatment with MTS.<\/jats:p>","DOI":"10.1177\/1087054710365986","type":"journal-article","created":{"date-parts":[[2010,4,21]],"date-time":"2010-04-21T22:25:44Z","timestamp":1271888744000},"page":"295-304","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Methylphenidate Transdermal System in Adult ADHD and Impact on Emotional and Oppositional Symptoms"],"prefix":"10.1177","volume":"15","author":[{"given":"Barrie K.","family":"Marchant","sequence":"first","affiliation":[{"name":"University of Utah,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Reimherr","sequence":"additional","affiliation":[{"name":"University of Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid J.","family":"Robison","sequence":"additional","affiliation":[{"name":"University of Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Olsen","sequence":"additional","affiliation":[{"name":"University of Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas G.","family":"Kondo","sequence":"additional","affiliation":[{"name":"University of Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,4,21]]},"reference":[{"key":"atypb1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association.","year":"1994","edition":"4"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0998-66"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.09.011"},{"key":"atypb4","volume-title":"Conners\u2019 Adult ADHD Rating Scales (CAARS)","author":"Conners, C.K.","year":"1999"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1097\/chi.0b013e31806ad1d7"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/1087054708314844"},{"key":"atypb7","first-page":"49","volume":"69","author":"Findling, R.L.","year":"2008","journal-title":"Journal of Clinical Psychiatry"},{"key":"atypb8","volume-title":"ECDEU assessment manual for psychopharmacology: Publication ADM 76-338","author":"Guy, W.","year":"1976"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200620090-00002"},{"key":"atypb10","volume-title":"Poster presentation in annual meeting of the American Psychiatric Association","author":"Jasinski, J.R."},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200102000-00009"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.4.716"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1177\/1087054705284089"},{"key":"atypb14","volume-title":"Characterization of dermal reactions with the use of methylphenidate transdermal system in pediatric subjects with attention-deficit\/hyperactivity disorder. 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