{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:11:41Z","timestamp":1777781501251,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T00:00:00Z","timestamp":1296604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Atten Disord"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Objective: To assess how threshold oppositional defiant disorder (ODD), inattention, and hyperactivity-impulsivity affect the response to atomoxetine versus methylphenidate. Method: Systematic review of randomized controlled trials (RCTs; \u22656 weeks follow-up). The primary measure was core symptom response\u2014\u226540% reduction in ADHD Rating Scale-IV\u2013Parent Version: investigator administered and scored total or domain subscores, as appropriate. Results: Data from 1,391 children and adolescents (823 atomoxetine, 568 methylphenidate; 7 RCTs) were meta-analyzed. The mean difference in response rates for patients with ODD was 0.6% (95% confidence interval [CI] = \u221211.9%-13.1%). The \u201cwithout ODD\u201d patient group showed significant between-trial heterogeneity ( p &lt; .001). Response rate differences for patients meeting the threshold for inattention or hyperactivity-impulsivity were \u22123.1% (95% CI = \u221211.5%-5.3%) and \u22124.9% (95% CI = \u221214.3%-4.4%), respectively. 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