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Method: Secondary analysis of a placebo-controlled study in ADHD patients (6-12 years old) treated with atomoxetine (target dose: 1.2 mg\/kg per day). Cb-CPT\/MT scores were analyzed using ANCOVA (last observation carried forward [LOCF]). Results: The data ( N = 125) suggested a more pronounced atomoxetine effect in the group with comorbid ODD\/CD as measured by all cb-CPT\/MT parameters except for \u201cnormalized variation of reaction time\u201d (nVRT). Conclusion: The results showed that atomoxetine reduced ADHD severity as measured by cb-CPT and MT parameters regardless of whether comorbid ODD\/CD was present. The treatment effect of atomoxetine on hyperactivity appears to be more pronounced in the subgroup of patients with comorbid ODD\/CD than in the subgroup without this comorbidity.<\/jats:p>","DOI":"10.1177\/1087054712456739","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T00:26:27Z","timestamp":1346199987000},"page":"591-602","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Does Comorbid Disruptive Behavior Modify the Effects of Atomoxetine on ADHD Symptoms as Measured by a Continuous Performance Test and a Motion Tracking Device?"],"prefix":"10.1177","volume":"19","author":[{"given":"Peter M.","family":"Wehmeier","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany"},{"name":"Vitos Hospital for Psychiatry and Psychotherapy, Weilmuenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kipp","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf W.","family":"Dittmann","sequence":"additional","affiliation":[{"name":"Eli Lilly Endowed Chair of Pediatric Psychopharmacology at the Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schacht","sequence":"additional","affiliation":[{"name":"Lilly Deutschland, Bad Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"bibr1-1087054712456739","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2000","edition":"4"},{"key":"bibr2-1087054712456739","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200923000-00005"},{"key":"bibr3-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-010-0090-z"},{"key":"bibr4-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1880"},{"key":"bibr5-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66915-2"},{"key":"bibr6-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0565-2"},{"key":"bibr7-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1080\/17405620801937764"},{"key":"bibr8-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1186\/1753-2000-1-10"},{"key":"bibr9-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.10.014"},{"key":"bibr10-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0840-x"},{"key":"bibr11-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2009.07.008"},{"key":"bibr12-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-005-1829-8"},{"key":"bibr13-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.03.011"},{"key":"bibr14-1087054712456739","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2009.0111"},{"key":"bibr15-1087054712456739","volume-title":"DISYPS-JK: Diagnostik-System f\u00fcr psyschiche St\u00f6rungen im Kindes- und Jugendalter nach ICD-10 und DSM-IV","author":"D\u00f6pfner M.","year":"2000"},{"key":"bibr16-1087054712456739","first-page":"21","volume":"67","author":"Doyle A. 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