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Method: Subjects were recruited from a population-based birth cohort. Participating adult subjects with childhood ADHD and non-ADHD controls were administered a structured psychiatric interview to assess suicidality and psychiatric comorbidities. Associations were assessed using logistic regression. Results: Compared with controls, ADHD cases were significantly more likely to meet criteria for suicidality. Subjects with childhood ADHD who met criteria for generalized anxiety disorder had a higher than expected risk of suicidality with an observed odds ratio of 10.94 (95% confidence interval [4.97, 24.08]) compared with an expected odds ratio of 4.86, consistent with a synergistic interaction effect. Significant synergistic interactions were also observed for hypomanic episode and substance-related disorders. Conclusion: Childhood ADHD is significantly associated with adult suicidal risk. Comorbidity between ADHD and some psychiatric disorders is associated with a higher suicidal risk than expected.<\/jats:p>","DOI":"10.1177\/1087054717718264","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T10:26:26Z","timestamp":1514715986000},"page":"777-786","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Psychiatric Comorbidities Modify the Association Between Childhood ADHD and Risk for Suicidality: A Population-Based Longitudinal Study"],"prefix":"10.1177","volume":"23","author":[{"given":"Kouichi","family":"Yoshimasu","sequence":"first","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"},{"name":"Wakayama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Barbaresi","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, 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