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Method: Assessment was conducted using European Addiction Severity Index (EuropASI), Conners\u2019 Adult ADHD Diagnostic Interview (CAADID), Structured Clinical Interview for DSM Disorders (SCID), Adult Self-Report Scale (ASRS), Wender Utah Rating Scale (WURS), Barratt Impulsiveness Scale-11 (BIS-11), and FIDI, with statistical analyses of analysis of variance (ANOVA), Student\u2019s t test, chi-square test, and multinomial regression model. Results: In total, 1,538 patients with substance use disorder (SUD) were evaluated for ADHD; 239 (15.5%) had ADHD, with cannabis 41, cannabis\/cocaine 36, and cocaine 74. Men represented 80%, with mean age of 32.9 \u00b1 10 years. Significant variables were\u2014in bivariate analysis\u2014more years of cannabis use in cannabis group and younger age for cocaine use disorder in cannabis\/cocaine group, and\u2014in multivariate analysis\u2014lifetime anxiety disorder and younger age at onset of any SUD in cannabis group and working affected scale in cannabis and polysubstance use in cannabis\/cocaine group. Conclusion: Groups with cannabis use had higher severity. ADHD features were similar in all groups. 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