{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:07:23Z","timestamp":1790680043412,"version":"4.1.0"},"reference-count":70,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["097818"],"award-info":[{"award-number":["097818"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Atten Disord"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>\n                    Objective: To identify clinical and central features that differentiate ADHD youth with and without familial risk for bipolar I disorder (BD). Methods: Psychostimulant-free ADHD youth (10\u201318\u2009years) with and without a first-degree relative with BD and healthy controls were enrolled. Bilateral ventrolateral prefrontal cortex (VLPFC) proton magnetic resonance spectroscopy (\n                    <jats:sup>1<\/jats:sup>\n                    H MRS) scans and a range of symptom ratings were performed. Results: A total of n\u2009=\u2009145 youth were enrolled. ADHD youth with a family history of BD exhibited greater manic and depressive symptom severity, ADHD hyperactivity\/impulsive symptom severity, and higher parent-reported ratings of dysregulation compared with ADHD youth without a BD family history. Although VLPFC metabolite levels did not differ across groups, choline levels in the left VLPFC correlated with different symptom ratings. Conclusion: Symptom profiles including more severe mood and externalizing symptoms, but not VLPFC neurochemistry, differentiate psychostimulant-free ADHD youth with and without a family history of BD.\n                  <\/jats:p>","DOI":"10.1177\/10870547221101645","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T02:30:53Z","timestamp":1654482653000},"page":"1762-1773","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Symptom Profiles, But Not Prefrontal Neurochemistry, Differentiate ADHD Youth With and Without a Family History of Bipolar I Disorder"],"prefix":"10.1177","volume":"26","author":[{"given":"Constance","family":"Chen","sequence":"first","affiliation":[{"name":"University of Cincinnati College of Medicine, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell J.","family":"Tallman","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M.","family":"Cecil","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center and University of Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Rodrigo","family":"Patino","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Blom","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P.","family":"DelBello","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9703-8114","authenticated-orcid":false,"given":"Robert K.","family":"McNamara","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,5]]},"reference":[{"key":"bibr1-10870547221101645","volume-title":"Manual for the ASEBA school-age forms & profiles","author":"Achenbach T. 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