{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:14:02Z","timestamp":1777781642220,"version":"3.51.4"},"reference-count":86,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2018-12367476"],"award-info":[{"award-number":["GR-2018-12367476"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Atten Disord"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To identify childhood psychopathological features that predict the onset of adolescent Bipolar (BD) versus Unipolar Major Depressive Disorder (UD) during adolescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We analyzed clinical data from 495 juveniles diagnosed with DSM-5 UD ( n\u2009=\u2009359), and BD ( n\u2009=\u2009136), using bivariate analysis and multivariate logistic regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>BD subjects exhibited earlier onset of any psychiatric feature compared to UD. Antecedents associated with later BD were: oppositional defiant\u2009&gt;\u2009specific phobias\u2009&gt;\u2009ADHD\u2009&gt;\u2009obsessive compulsive (OCD). Antecedents selectively associated with later UD were: social anxiety and separation anxiety. Factors significantly and independently associated with later BD diagnosis were: [a] emotional dysregulation at onset of the mood disorder; [b] first depressive episode with mixed features; [c] antecedent ADHD; [d] antecedent OCD, and [e] antecedent oppositional-defiance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Identifying developmental differences in BD and UD symptoms can aid clinicians in early identification and treatment planning for bipolar disorder in youth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10870547231225819","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T01:45:50Z","timestamp":1707356750000},"page":"648-663","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Childhood Clinical Features Preceding the Onset of Bipolar Versus Major Depressive Disorders During Adolescence"],"prefix":"10.1177","volume":"28","author":[{"given":"Clotilde","family":"Guidetti","sequence":"first","affiliation":[{"name":"Child & Adolescent Neuropsychiatry Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"},{"name":"Life Sciences and Public Health Department, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7005-3736","authenticated-orcid":false,"given":"Giulia","family":"Serra","sequence":"additional","affiliation":[{"name":"Child & Adolescent Neuropsychiatry Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-5773","authenticated-orcid":false,"given":"Massimo","family":"Apicella","sequence":"additional","affiliation":[{"name":"Child & Adolescent Neuropsychiatry Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Andracchio","sequence":"additional","affiliation":[{"name":"Child & Adolescent Neuropsychiatry Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Iannoni","sequence":"additional","affiliation":[{"name":"Child & Adolescent Neuropsychiatry Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-8410","authenticated-orcid":false,"given":"Monia","family":"Trasolini","sequence":"additional","affiliation":[{"name":"Child & Adolescent Neuropsychiatry Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Della Santa","sequence":"additional","affiliation":[{"name":"Child & Adolescent Neuropsychiatry Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino","family":"Maglio","sequence":"additional","affiliation":[{"name":"Child & Adolescent Neuropsychiatry Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Vicari","sequence":"additional","affiliation":[{"name":"Child & Adolescent Neuropsychiatry Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"},{"name":"Life Sciences and Public Health Department, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"bibr1-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)90025-6"},{"key":"bibr2-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"bibr3-10870547231225819","doi-asserted-by":"publisher","DOI":"10.17795\/ijpbs-3604"},{"key":"bibr4-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00424"},{"key":"bibr5-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-005-0576-8"},{"key":"bibr6-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1089\/104454603322724850"},{"key":"bibr7-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.159.3.298-a"},{"key":"bibr8-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.10.033"},{"key":"bibr9-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.wpsyc.2012.01.006"},{"key":"bibr10-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.1999.10106.x"},{"key":"bibr11-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.07.032"},{"key":"bibr12-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830050073012"},{"key":"bibr13-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.12.003"},{"key":"bibr14-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00906-9"},{"key":"bibr15-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00911-2"},{"key":"bibr16-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.02.024"},{"key":"bibr17-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707002668"},{"key":"bibr18-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.02.016"},{"key":"bibr19-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12170"},{"key":"bibr20-10870547231225819","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0505"},{"key":"bibr21-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800300079011"},{"key":"bibr22-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1159\/000096364"},{"key":"bibr23-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu169"},{"key":"bibr24-10870547231225819","unstructured":"Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. (2018). Web-based injury statistics query and reporting system (WISQARS). https:\/\/www.cdc.gov\/injury\/"},{"key":"bibr25-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.85"},{"key":"bibr26-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.07.783"},{"issue":"5","key":"bibr27-10870547231225819","first-page":"427","volume":"67","author":"Donfrancesco R.","year":"2015","journal-title":"Minerva Pediatrics"},{"key":"bibr28-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.05.022"},{"issue":"1","key":"bibr29-10870547231225819","first-page":"6","volume":"22","author":"Duffy A.","year":"2013","journal-title":"Journal of the Canadian Academy of Child and Adolescent Psychiatry"},{"key":"bibr30-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200010000-00011"},{"key":"bibr31-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2003.12.011"},{"key":"bibr32-10870547231225819","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13r08900"},{"key":"bibr33-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.07.013"},{"key":"bibr34-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12899"},{"key":"bibr35-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01512.x"},{"key":"bibr36-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199405000-00003"},{"key":"bibr37-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphysparis.2013.03.006"},{"key":"bibr38-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2014.06.004"},{"key":"bibr39-10870547231225819","first-page":"3","volume":"49","author":"Goldstein B. I.","year":"2012","journal-title":"Israel Journal of Psychiatry and Related Sciences"},{"key":"bibr40-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(01)00357-2"},{"key":"bibr41-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.02.011"},{"key":"bibr42-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.03.019"},{"key":"bibr43-10870547231225819","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11040434"},{"key":"bibr44-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.10.1679"},{"key":"bibr45-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199707000-00021"},{"key":"bibr46-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291799008375"},{"key":"bibr47-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.7.709"},{"key":"bibr48-10870547231225819","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05587blu"},{"key":"bibr49-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e3181a56606"},{"key":"bibr50-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.02.005"},{"key":"bibr51-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2003.09.009"},{"key":"bibr52-10870547231225819","author":"Kovacs M.","year":"2011","journal-title":"Children\u2019s depression inventory 2nd edition: Technical manual"},{"key":"bibr53-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(95)00008-B"},{"key":"bibr54-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-014-9884-7"},{"key":"bibr55-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e31816765e7"},{"key":"bibr56-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6185(97)00017-0"},{"key":"bibr57-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)90104-X"},{"key":"bibr58-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1177\/070674370104600902"},{"key":"bibr59-10870547231225819","author":"March J.S.","year":"2012","journal-title":"Multidimensional anxiety scale for children"},{"key":"bibr60-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2010.0063"},{"key":"bibr61-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113231"},{"key":"bibr62-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.1.56"},{"key":"bibr63-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10111704"},{"key":"bibr64-10870547231225819","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04994yel"},{"key":"bibr65-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198403000-00011"},{"key":"bibr66-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.3140"},{"key":"bibr67-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.466"},{"key":"bibr68-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12170"},{"key":"bibr69-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.05.063"},{"key":"bibr70-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.10.050"},{"key":"bibr71-10870547231225819","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160607100403"},{"key":"bibr72-10870547231225819","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11040440"},{"key":"bibr73-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.05.037"},{"key":"bibr74-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.10.003"},{"key":"bibr75-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00092-5"},{"key":"bibr76-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.3.251"},{"key":"bibr77-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08121849"},{"key":"bibr78-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290050029007"},{"key":"bibr79-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01012-1"},{"key":"bibr80-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01523.x"},{"key":"bibr81-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.05.049"},{"key":"bibr82-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.01.037"},{"key":"bibr83-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2016.04.014"},{"key":"bibr84-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1002\/da.22248"},{"key":"bibr85-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.05.013"},{"key":"bibr86-10870547231225819","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.10.063"}],"container-title":["Journal of Attention Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10870547231225819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10870547231225819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10870547231225819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:29:57Z","timestamp":1777490997000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10870547231225819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":86,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1177\/10870547231225819"],"URL":"https:\/\/doi.org\/10.1177\/10870547231225819","relation":{},"ISSN":["1087-0547","1557-1246"],"issn-type":[{"value":"1087-0547","type":"print"},{"value":"1557-1246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,7]]}}}