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Our objective was to examine these mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      In this study, we leverage a high-quality longitudinal dataset, the Millennium Cohort Study (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20092,607 male,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20092,791 female) to simultaneously evaluate a range of hypothesised mediating mechanisms. These include indirect effects via peer problems, conduct problems, self-esteem, injuries and accidents, relationships with parents, academic performance, risky decision-making, parental mental health, educational motivation, and general health. We used exploratory longitudinal mediation analysis with regularised structural equation modelling (regSEM) to examine 14 candidate mediators of the ADHD-internalising association across ages 11, 14 and 17.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Regularisation with lasso did not result in the de-selection of any of these mediators; however, only two were statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Results suggest there may be many mediators of small effect involved in the relation between ADHD symptoms and later internalising problems but point to self-esteem and parental mental health as priority mechanisms for further study in future causal and interventional research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10870547261419589","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:42:55Z","timestamp":1773243775000},"page":"986-998","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Candidate Mediators Linking ADHD Symptoms and Internalising Problems in Adolescence: An Exploratory Longitudinal Mediation Analysis"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9068-3188","authenticated-orcid":false,"given":"Aja Louise","family":"Murray","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Dryburgh","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund J. 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