{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:50:52Z","timestamp":1771012252147,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":3481,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["slas-discovery.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Discovery"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1177\/1087057112449864","type":"journal-article","created":{"date-parts":[[2012,6,17]],"date-time":"2012-06-17T17:39:17Z","timestamp":1339954757000},"page":"1192-1203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Determination of Appropriate Stage of Human-Induced Pluripotent Stem Cell\u2013Derived Cardiomyocytes for Drug Screening and Pharmacological Evaluation In Vitro"],"prefix":"10.1016","volume":"17","author":[{"given":"Tadahiro","family":"Shinozawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Imahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatsue","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Takami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1177\/1087057112449864_bib1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1177\/1087057112449864_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nbt1374","article-title":"Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts","volume":"26","author":"Nakagawa","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1177\/1087057112449864_bib3","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic Stem Cell Lines Derived from Human Blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1177\/1087057112449864_bib4","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1177\/1087057112449864_bib5","doi-asserted-by":"crossref","first-page":"796","DOI":"10.7150\/ijbs.6.796","article-title":"Applications of Patient-Specific Induced Pluripotent Stem Cells; Focused on Disease Modeling, Drug Screening and Therapeutic Potentials for Liver Disease","volume":"6","author":"Chun","year":"2010","journal-title":"Int. J. Biol. Sci."},{"key":"10.1177\/1087057112449864_bib6","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/labinvest.2011.85","article-title":"Induced Pluripotent Stem Cells as a Next-Generation Biomedical Interface","volume":"91","author":"Hankowski","year":"2011","journal-title":"Lab. Invest."},{"key":"10.1177\/1087057112449864_bib7","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/CIRCRESAHA.108.192237","article-title":"Functional Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells","volume":"104","author":"Zhang","year":"2009","journal-title":"Circ. Res."},{"key":"10.1177\/1087057112449864_bib8","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1161\/CIRCULATIONAHA.109.868885","article-title":"Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells","volume":"120","author":"Zwi","year":"2009","journal-title":"Circulation"},{"key":"10.1177\/1087057112449864_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1582-4934.2009.00996.x","article-title":"Molecular Characterization and Functional Properties of Cardiomyocytes Derived from Human Inducible Pluripotent Stem Cells","volume":"15","author":"Germanguz","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1177\/1087057112449864_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1160\/TH10-05-0269","article-title":"Future Perspective of Induced Pluripotent Stem Cells for Diagnosis, Drug Screening and Treatment of Human Diseases","volume":"104","author":"Lian","year":"2010","journal-title":"Thromb. Haemost."},{"key":"10.1177\/1087057112449864_bib11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jat.1663","article-title":"Cardiotoxicity Testing Using Pluripotent Stem Cell-Derived Human Cardiomyocytes and State-of-the-Art Bioanalytics: A Review","volume":"31","author":"Mandenius","year":"2011","journal-title":"J. Appl. Toxicol."},{"key":"10.1177\/1087057112449864_bib12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbrc.2009.05.073","article-title":"In Vitro Pharmacologic Testing Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes","volume":"385","author":"Tanaka","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1177\/1087057112449864_bib13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bbrc.2009.07.052","article-title":"The Effects of Cardioactive Drugs on Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells","volume":"387","author":"Yokoo","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1177\/1087057112449864_bib14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/cvr\/cvr132","article-title":"Pharmacological Response of Human Cardiomyocytes Derived from Virus-Free Induced Pluripotent Stem Cells","volume":"91","author":"Mehta","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1177\/1087057112449864_bib15","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1634\/stemcells.2007-0549","article-title":"Functional Sarcoplasmic Reticulum for Calcium Handling of Human Embryonic Stem Cell-Derived Cardiomyocytes: Insights for Driven Maturation","volume":"25","author":"Liu","year":"2007","journal-title":"Stem Cells"},{"key":"10.1177\/1087057112449864_bib16","doi-asserted-by":"crossref","first-page":"H2355","DOI":"10.1152\/ajpheart.00020.2003","article-title":"Assessment of the Ultrastructural and Proliferative Properties of Human Embryonic Stem Cell-Derived Cardiomyocytes","volume":"285","author":"Snir","year":"2003","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1177\/1087057112449864_bib17","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1634\/stemcells.2006-0466","article-title":"Developmental Changes in Cardiomyocytes Differentiated from Human Embryonic Stem Cells: A Molecular and Electrophysiological Approach","volume":"25","author":"Sartiani","year":"2007","journal-title":"Stem Cells"},{"key":"10.1177\/1087057112449864_bib18","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1634\/stemcells.2007-1033","article-title":"Molecular Signature of Cardiomyocyte Clusters Derived from Human Embryonic Stem Cells","volume":"26","author":"Synnergren","year":"2008","journal-title":"Stem Cells"},{"key":"10.1177\/1087057112449864_bib19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1471-213X-10-98","article-title":"Global Transcriptional Profiles of Beating Clusters Derived from Human Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Highly Similar","volume":"10","author":"Gupta","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1177\/1087057112449864_bib20","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature06894","article-title":"Human Cardiovascular Progenitor Cells Develop from a KDR+ Embryonic-Stem-Cell-Derived Population","volume":"453","author":"Yang","year":"2008","journal-title":"Nature"},{"key":"10.1177\/1087057112449864_bib21","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1177\/1087057111434145","article-title":"Novel Purification Method of Murine Embryonic Stem Cell- and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Simple Manual Dissociation","volume":"17","author":"Shinozawa","year":"2012","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/1087057112449864_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/1087057108330112","article-title":"Gene Expression Profiling of Functional Murine Embryonic Stem Cell-Derived Cardiomyocytes and Comparison with Adult Heart: Profiling of Murine ESC-Derived Cardiomyocytes","volume":"14","author":"Shinozawa","year":"2009","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/1087057112449864_bib23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jelectrocard.2004.08.034","article-title":"Determination of Electrical Properties of ES Cell-Derived Cardiomyocytes Using MEAs","volume":"37 Suppl","author":"Hescheler","year":"2004","journal-title":"J. Electrocardiol."},{"key":"10.1177\/1087057112449864_bib24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jelectrocard.2005.06.029","article-title":"The Electrocardiogram of Human Embryonic Stem Cell-Derived Cardiomyocytes","volume":"38","author":"Reppel","year":"2005","journal-title":"J. Electrocardiol."},{"key":"10.1177\/1087057112449864_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000100628","article-title":"Effect of Cardioactive Drugs on Action Potential Generation and Propagation in Embryonic Stem Cell-Derived Cardiomyocytes","volume":"19","author":"Reppel","year":"2007","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1177\/1087057112449864_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.RES.0000080317.92718.99","article-title":"Human Embryonic Stem Cells Develop into Multiple Types of Cardiac Myocytes: Action Potential Characterization","volume":"93","author":"He","year":"2003","journal-title":"Circ. Res."},{"key":"10.1177\/1087057112449864_bib27","doi-asserted-by":"crossref","first-page":"e18037","DOI":"10.1371\/journal.pone.0018037","article-title":"Calcium Handling in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes","volume":"6","author":"Itzhaki","year":"2011","journal-title":"PLoS. One."},{"key":"10.1177\/1087057112449864_bib28","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1113\/jphysiol.2009.172098","article-title":"New Roles of Calsequestrin and Triadin in Cardiac Muscle","volume":"587","author":"Knollmann","year":"2009","journal-title":"J. Physiol."},{"key":"10.1177\/1087057112449864_bib29","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.yjmcc.2010.08.012","article-title":"S100A1 Gene Therapy for Heart Failure: A Novel Strategy on the Verge of Clinical Trials","volume":"50","author":"Rohde","year":"2011","journal-title":"J. Mol. Cell. Cardiol."}],"container-title":["SLAS Discovery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1087057112449864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1087057112449864","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222076973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222076973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1087057112449864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:38:25Z","timestamp":1762861105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472555222076973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S2472555222076973"],"URL":"https:\/\/doi.org\/10.1177\/1087057112449864","relation":{},"ISSN":["2472-5552"],"issn-type":[{"value":"2472-5552","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of Appropriate Stage of Human-Induced Pluripotent Stem Cell\u2013Derived Cardiomyocytes for Drug Screening and Pharmacological Evaluation In Vitro","name":"articletitle","label":"Article Title"},{"value":"SLAS Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1177\/1087057112449864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Society for Laboratory Automation and Screening. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}