{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:50:04Z","timestamp":1791078604449,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":3114,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["slas-discovery.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Discovery"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1177\/1087057113484802","type":"journal-article","created":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T00:01:46Z","timestamp":1365206506000},"page":"984-996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Phenotypic Screening Assay for Modulators of Huntingtin-Induced Transcriptional Dysregulation"],"prefix":"10.1016","volume":"18","author":[{"given":"Giulia","family":"Lazzeroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Benicchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Heitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Magnoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Diamanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Rossini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Massai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Federico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Fecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Caricasole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"La Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Porcari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1177\/1087057113484802_bib1","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1517\/13543784.16.12.1933","article-title":"Huntington\u2019s Disease: Progress and Potential in the Field","volume":"16","author":"Stack","year":"2007","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1177\/1087057113484802_bib2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng0893-398","article-title":"The Relationship between Trinucleotide (CAG) Repeat Length and Clinical Features of Huntington\u2019s Disease","volume":"4","author":"Andrew","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1177\/1087057113484802_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2011.12.013","article-title":"Protein Aggregates in Huntington\u2019s Disease","volume":"238","author":"Arrasate","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1177\/1087057113484802_bib4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2202-7-80","article-title":"Wild-Type Huntingtin Ameliorates Striatal Neuronal Atrophy but Does Not Prevent Other Abnormalities in the YAC128 Mouse Model of Huntington Disease","volume":"7","author":"Van Raamsdonk","year":"2006","journal-title":"BMC Neurosci."},{"key":"10.1177\/1087057113484802_bib5","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/nm1106-1239","article-title":"Transcription Meets Metabolism in Neurodegeneration","volume":"12","author":"Ross","year":"2006","journal-title":"Nat Med."},{"key":"10.1177\/1087057113484802_bib6","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1371\/journal.pgen.0030082","article-title":"Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration","volume":"3","author":"Kaltenbach","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1177\/1087057113484802_bib7","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","article-title":"Decreased expression of striatal signaling genes in a mouse model of Huntington\u2019s disease","volume":"9","author":"Luthi-Carter","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1177\/1087057113484802_bib8","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/emboj.2008.23","article-title":"Mutant Huntingtin Reduces HSP70 Expression through the Sequestration of NF-Y Transcription Factor","volume":"27","author":"Yamanaka","year":"2008","journal-title":"EMBO J."},{"key":"10.1177\/1087057113484802_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2005.06.005","article-title":"p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington\u2019s Disease","volume":"47","author":"Bae","year":"2005","journal-title":"Neuron"},{"key":"10.1177\/1087057113484802_bib10","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1126\/science.1072613","article-title":"Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington\u2019s Disease","volume":"296","author":"Dunah","year":"2002","journal-title":"Science"},{"key":"10.1177\/1087057113484802_bib11","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1126\/science.1056784","article-title":"Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity","volume":"291","author":"Nucifora","year":"2001","journal-title":"Science"},{"key":"10.1177\/1087057113484802_bib12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.nbd.2010.02.003","article-title":"The Role of REST in Transcriptional and Epigenetic Dysregulation in Huntington\u2019s Disease","volume":"39","author":"Buckley","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1177\/1087057113484802_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional Repression of PGC-1alpha by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration","volume":"6","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"10.1177\/1087057113484802_bib14","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1093\/hmg\/ddn273","article-title":"Inhibition of Specific HDACs and Sirtuins Suppresses Pathogenesis in a Drosophila Model of Huntington\u2019s Disease","volume":"17","author":"Pallos","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1177\/1087057113484802_bib15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nm.2558","article-title":"Neuroprotective Role of Sirt1 in Mammalian Models of Huntington\u2019s Disease through Activation of Multiple Sirt1 Targets","volume":"18","author":"Jiang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1177\/1087057113484802_bib16","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/hmg\/10.17.1829","article-title":"Polyglutamine Expansions Cause Decreased CRE-Mediated Transcription and Early Gene Expression Changes Prior to Cell Death in an Inducible Cell Model of Huntington\u2019s Disease","volume":"10","author":"Wyttenbach","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1177\/1087057113484802_bib17","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1074\/jbc.M310226200","article-title":"Decreased cAMP Response Element-Mediated Transcription: An Early Event in Exon 1 and Full-Length Cell Models of Huntington\u2019s Disease That Contributes to Polyglutamine Pathogenesis","volume":"279","author":"Sugars","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1177\/1087057113484802_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.07080.x","article-title":"CREB: A Multifaceted Regulator of Neuronal Plasticity and Protection","volume":"116","author":"Sakamoto","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1177\/1087057113484802_bib19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.nbd.2006.04.011","article-title":"Depletion of CBP Is Directly Linked with Cellular Toxicity Caused by Mutant Huntingtin","volume":"23","author":"Jiang","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1177\/1087057113484802_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mcn.2005.05.003","article-title":"Mutant Huntingtin Represses CBP, but Not p300, by Binding and Protein Degradation","volume":"30","author":"Cong","year":"2005","journal-title":"Mol. Cell Neurosci."},{"key":"10.1177\/1087057113484802_bib21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.drudis.2009.02.006","article-title":"Small Molecule Drug Discovery for Huntington\u2019s Disease","volume":"14","author":"Fecke","year":"2009","journal-title":"Drug Discov. Today"},{"key":"10.1177\/1087057113484802_bib22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/1874467211003030164","article-title":"Drug Screening for Huntington\u2019s Disease and Other Neurodegenerative Disorders","volume":"3","author":"Varma","year":"2010","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1177\/1087057113484802_bib23","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1074\/jbc.M111.294801","article-title":"A Screen for Enhancers of Clearance Identifies Huntingtin as a Heat Shock Protein 90 (Hsp90) Client Protein","volume":"287","author":"Baldo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1177\/1087057113484802_bib24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/1087057107299428","article-title":"Discovery of a Novel Small-Molecule Targeting Selective Clearance of Mutant Huntingtin Fragments","volume":"12","author":"Coufal","year":"2007","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/1087057113484802_bib25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0896-6273(03)00697-4","article-title":"A Rapid Cellular FRET Assay of Polyglutamine Aggregation Identifies a Novel Inhibitor","volume":"40","author":"Pollitt","year":"2003","journal-title":"Neuron"},{"key":"10.1177\/1087057113484802_bib26","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.nbd.2004.04.001","article-title":"A Cell-Based Screen for Drugs to Treat Huntington\u2019s Disease","volume":"16","author":"Aiken","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1177\/1087057113484802_bib27","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.nbd.2005.03.026","article-title":"Compounds Blocking Mutant Huntingtin Toxicity Identified Using a Huntington\u2019s Disease Neuronal Cell Model","volume":"20","author":"Wang","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1177\/1087057113484802_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nchembio852","article-title":"Selective Inhibitors of Death in Mutant Huntingtin Cells","volume":"3","author":"Varma","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1177\/1087057113484802_bib29","article-title":"Long-Term Memory Deficits in Huntington\u2019s Disease Are Associated with Reduced CBP Histone Acetylase Activity","volume":"15","author":"Giralt","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1177\/1087057113484802_bib30","series-title":"Assay Guidance Manual","year":"2004"},{"key":"10.1177\/1087057113484802_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/1087057113484802_bib32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.nbd.2009.06.011","article-title":"Y-27632 Improves Rotarod Performance and Reduces Huntingtin Levels in R6\/2 Mice","volume":"36","author":"Li","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1177\/1087057113484802_bib33","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0026-895X(24)26508-1","article-title":"Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases","volume":"57","author":"Ishizaki","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1177\/1087057113484802_bib34","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2741\/2710","article-title":"Diverse Roles of Rho Family GTPases in Neuronal Development, Survival, and Death","volume":"13","author":"Linseman","year":"2008","journal-title":"Frontiers Biosci."},{"key":"10.1177\/1087057113484802_bib35","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1096\/fj.01-0995fje","article-title":"Preferential Transformation of Human Neuronal Cells by Human Adenoviruses and the Origin of HEK 293 Cells","volume":"16","author":"Shaw","year":"2002","journal-title":"FASEB J."}],"container-title":["SLAS Discovery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1087057113484802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1087057113484802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222075451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222075451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1087057113484802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:40:58Z","timestamp":1762861258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472555222075451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S2472555222075451"],"URL":"https:\/\/doi.org\/10.1177\/1087057113484802","relation":{},"ISSN":["2472-5552"],"issn-type":[{"value":"2472-5552","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Phenotypic Screening Assay for Modulators of Huntingtin-Induced Transcriptional Dysregulation","name":"articletitle","label":"Article Title"},{"value":"SLAS Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1177\/1087057113484802","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Society for Laboratory Automation and Screening. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}