{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:07:10Z","timestamp":1793704030123,"version":"4.5.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":3016,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["slas-discovery.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Discovery"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1177\/1087057113502851","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:37:58Z","timestamp":1378255078000},"page":"66-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Detection of Phospholipidosis Induction: A Cell-Based Assay in High-Throughput and High-Content Format"],"prefix":"10.1016","volume":"19","author":[{"given":"Sampada A.","family":"Shahane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gerhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Baxa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Austin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1177\/1087057113502851_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0041-008X(89)90054-9","article-title":"A Review of the Biology and Toxicologic Implications of the Induction of Lysosomal Lamellar Bodies by Drugs","volume":"97","author":"Reasor","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1177\/1087057113502851_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3181\/00379727-212-44019","article-title":"An Evaluation of Possible Mechanisms Underlying Amiodarone-Induced Pulmonary Toxicity","volume":"212","author":"Reasor","year":"1996","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1177\/1087057113502851_bib3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0041-008X(89)90055-0","article-title":"Disobutamide: A Model Agent for Investigating Intracellular Drug Storage","volume":"97","author":"Ruben","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1177\/1087057113502851_bib4","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.3748\/wjg.v11.i34.5394","article-title":"Liver Cirrhosis Induced by Long-Term Administration of a Daily Low Dose of Amiodarone: A Case Report","volume":"11","author":"Oikawa","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1177\/1087057113502851_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ki.1980.175","article-title":"Aminoglycoside Nephrotoxicity","volume":"18","author":"Kaloyanides","year":"1980","journal-title":"Kidney Int."},{"key":"10.1177\/1087057113502851_bib6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1517\/14740338.5.4.567","article-title":"Drug-Induced Phospholipidosis: Issues and Future Directions","volume":"5","author":"Reasor","year":"2006","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1177\/1087057113502851_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF00223481","article-title":"Amiodarone\u2014an Inhibitor of Phospholipase Activity: A Comparative Study of the Inhibitory Effects of Amiodarone, Chloroquine and Chlorpromazine","volume":"76","author":"Shaikh","year":"1987","journal-title":"Mol. Cell Biochem."},{"key":"10.1177\/1087057113502851_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0005-2760(89)90078-7","article-title":"Fluorescence Studies on Binding of Amphiphilic Drugs to Isolated Lamellar Bodies: Relevance to Phospholipidosis","volume":"1004","author":"Joshi","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1177\/1087057113502851_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/faat.1996.0123","article-title":"In Vitro and In Vivo Ultrastructural Changes Induced by Macrolide Antibiotic LY281389","volume":"32","author":"Horn","year":"1996","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1177\/1087057113502851_bib10","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/0006-2952(90)90078-Y","article-title":"Aminoglycoside-Induced Renal Phospholipidosis and Nephrotoxicity","volume":"40","author":"Laurent","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"10.1177\/1087057113502851_bib11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0041-008X(89)90061-6","article-title":"Amiodarone-Induced Pulmonary Toxicity in Rats: Biochemical and Pharmacological Characteristics","volume":"97","author":"Reasor","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1177\/1087057113502851_bib12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/01926230701196414","article-title":"Phospholipidosis in Nonclinical Toxicity Studies","volume":"35","author":"Berridge","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1177\/1087057113502851_bib13","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0006-2952(01)00823-1","article-title":"Analysis of Two Matrix Metalloproteinase Inhibitors and Their Metabolites for Induction of Phospholipidosis in Rat and Human Hepatocytes(1)","volume":"62","author":"Gum","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1177\/1087057113502851_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10565-006-0176-z","article-title":"Validation of an In Vitro Screen for Phospholipidosis Using a High-Content Biology Platform","volume":"22","author":"Morelli","year":"2006","journal-title":"Cell Biol. Toxicol."},{"key":"10.1177\/1087057113502851_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/toxsci\/kfj067","article-title":"Establishment of an In Vitro High-Throughput Screening Assay for Detecting Phospholipidosis-Inducing Potential","volume":"90","author":"Kasahara","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1177\/1087057113502851_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1023\/A:1024778329320","article-title":"A Cell-Based Approach for the Early Assessment of the Phospholipidogenic Potential in Pharmaceutical Research and Drug Development","volume":"19","author":"Casartelli","year":"2003","journal-title":"Cell Biol. Toxicol."},{"key":"10.1177\/1087057113502851_bib17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/toxsci\/kfm157","article-title":"In Vitro Detection of Drug-Induced Phospholipidosis Using Gene Expression and Fluorescent Phospholipid Based Methodologies","volume":"99","author":"Nioi","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1177\/1087057113502851_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physiolgenomics.00161.2011","article-title":"Application of a Homogenous Membrane Potential Assay to Assess Mitochondrial Function","volume":"44","author":"Sakamuru","year":"2012","journal-title":"Physiol. Genomics"},{"key":"10.1177\/1087057113502851_bib19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/adt.2007.119","article-title":"Phospholipidosis Assay in HepG2 Cells and Rat or Rhesus Hepatocytes Using Phospholipid Probe NBD-PE","volume":"6","author":"Bhandari","year":"2008","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1177\/1087057113502851_bib20","series-title":"Handbook of Drug Screening","first-page":"442","article-title":"Enabling the Large Scale Analysis of Quantitative High Throughput Screening Data","author":"Southall","year":"2009"},{"key":"10.1177\/1087057113502851_bib21","unstructured":"Muehlbacher, M., Tripal, P., Roas, F., et al. Identification of Drugs Inducing Phospholipidosis by Novel In Vitro Data. ChemMedChem, in press."},{"key":"10.1177\/1087057113502851_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00705806","article-title":"Effects of Several Lipidosis-Including Drugs upon the Area Postrema and Adjacent Medullary Nuclei of Adult Rats, I: Alterations in Perikarya and Dendrites","volume":"52","author":"Frisch","year":"1980","journal-title":"Acta Neuropathol."},{"key":"10.1177\/1087057113502851_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/15376510701857262","article-title":"Development of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models","volume":"18","author":"Kruhlak","year":"2008","journal-title":"Toxicol. Mech. Methods."},{"key":"10.1177\/1087057113502851_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0022-3565(25)20091-X","article-title":"Gentamicin or Chlorphentermine Induction of Phospholipidosis in the Developing Organism: Role of Tissue and Species in Manifestation of Toxicity","volume":"232","author":"Kacew","year":"1985","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1177\/1087057113502851_bib25","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/toxsci\/kfh264","article-title":"A Toxicogenomic Approach to Drug-Induced Phospholipidosis: Analysis of Its Induction Mechanism and Establishment of a Novel In Vitro Screening System","volume":"83","author":"Sawada","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1177\/1087057113502851_bib26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0031-6997(25)00049-3","article-title":"Cationic Amphiphilic Drugs and Phospholipid Storage Disorder","volume":"42","author":"Kodavanti","year":"1990","journal-title":"Pharmacol. Rev."},{"key":"10.1177\/1087057113502851_bib27","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1517\/14656566.5.8.1807","article-title":"A Review of the Second-Generation Antihistamine Ebastine for the Treatment of Allergic Disorders","volume":"5","author":"Van Cauwenberge","year":"2004","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1177\/1087057113502851_bib28","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1136\/heart.89.11.1363","article-title":"Drug Induced QT Prolongation and Torsades de Pointes","volume":"89","author":"Yap","year":"2003","journal-title":"Heart"},{"key":"10.1177\/1087057113502851_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0022-3565(24)36589-9","article-title":"Suppression of Mammalian K+ Channel Family by Ebastine","volume":"281","author":"Ko","year":"1997","journal-title":"J Pharmacol. Exp. Ther."},{"key":"10.1177\/1087057113502851_bib30","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0166-4328(96)00089-7","article-title":"GR127935: A Potent and Selective 5-HT1D Receptor Antagonist","volume":"73","author":"Skingle","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1177\/1087057113502851_bib31","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0022-3565(25)12919-4","article-title":"4-(2\u2032-Methoxyphenyl)-1-[2\u2032-[N-(2\u2032\u2032-Pyridinyl)-p-iodobenzamido]ethyl] Piperazine and 4-(2\u2032-Methoxyphenyl)-1-[2\u2032-[N-(2\u2032\u2032-Pyridinyl)-p- Fluorobenzamido]ethyl]piperazine, Two New Antagonists at Pre- and Postsynaptic Serotonin-1A Receptors","volume":"277","author":"Thielen","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1177\/1087057113502851_bib32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-0270(90)90045-H","article-title":"Application of Brain Microdialysis to Study the Pharmacology of the 5-HT1A Autoreceptor","volume":"34","author":"Sharp","year":"1990","journal-title":"J. Neurosci. Methods"},{"key":"10.1177\/1087057113502851_bib33","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1192\/bjp.195.52.s13","article-title":"Psychopharmacology and Adverse Effects of Antipsychotic Long-Acting Injections: A Review","volume":"52","author":"Taylor","year":"2009","journal-title":"Br. J. Psychiatry Suppl."},{"key":"10.1177\/1087057113502851_bib34","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1023\/A:1020796200769","article-title":"Clozapine and Several Other Antipsychotic\/Antidepressant Drugs Preferentially Block the Same \u2018Core\u2019 Fraction of GABA(A) Receptors","volume":"23","author":"Squires","year":"1998","journal-title":"Neurochem. Res."},{"key":"10.1177\/1087057113502851_bib35","unstructured":"Cerep Phospholipidosis Application Note. http:\/\/www.cerep.fr\/cerep\/users\/pages\/downloads\/Documents\/Marketing\/Pharmacology%20&%20ADME\/Application%20notes\/2011%20Phospholipidosis.pdf"}],"container-title":["SLAS Discovery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1087057113502851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1087057113502851","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222073129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222073129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1087057113502851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:39:18Z","timestamp":1762861158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472555222073129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S2472555222073129"],"URL":"https:\/\/doi.org\/10.1177\/1087057113502851","relation":{},"ISSN":["2472-5552"],"issn-type":[{"value":"2472-5552","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection of Phospholipidosis Induction: A Cell-Based Assay in High-Throughput and High-Content Format","name":"articletitle","label":"Article Title"},{"value":"SLAS Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1177\/1087057113502851","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Society for Laboratory Automation and Screening. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}