{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:27Z","timestamp":1792787727633,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Centro de Investigaci\u00f3n Biotecnol\u00f3gica en Red de Enfermedades Infecciosas","award":["CB21\/13\/00091"],"award-info":[{"award-number":["CB21\/13\/00091"]}],"id":[{"id":"https:\/\/ror.org\/00nd8zg79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Gilead Sciences","award":["25394"],"award-info":[{"award-number":["25394"]}],"id":[{"id":"https:\/\/ror.org\/056546b03","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AIDS Patient Care and STDs"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>\n                    The postpartum period remains a vulnerable phase for maintaining virologic suppression among women with HIV (WWH); however, evidence on postpartum virologic failure (VF) among women virologically suppressed at delivery is limited. We analyzed data from the CoRIS cohort including WWH aged 18\u201350 years who had a live birth while receiving antiretroviral therapy (ART) and were virologically suppressed at delivery between 2004 and 2024. The primary outcome was time to VF within 12 months postpartum, defined as two consecutive HIV RNA measurements &gt;50 copies\/mL or a single measurement &gt;1000 copies\/mL. Secondary outcomes included virologic non-suppression\u00a0(VnS) and CD4\n                    <jats:sup>+<\/jats:sup>\n                    cell count changes at 12 months postpartum. Kaplan\u2013Meier and Cox models were used to assess time to VF and generalized estimating equations (logistic and linear model) to evaluate VnS and CD4\n                    <jats:sup>+<\/jats:sup>\n                    changes, accounting for repeated deliveries. The analysis included 422 deliveries among 337 women. The cumulative incidence of VF was 15.7% (95% CI: 12.1\u201319.1) at 12 months postpartum. VF risk was lower in more recent calendar periods. At 12 months postpartum, 18.0% of deliveries showed VnS. Earlier calendar periods, younger maternal age, and protease inhibitor\u2013based ART regimens were associated with higher odds of non-suppression. Mean CD4\n                    <jats:sup>+<\/jats:sup>\n                    cell counts increased by 88.5 cells\/\u00b5L overall, with greater improvements in more recent years. Postpartum ART discontinuation decreased markedly over time, alongside increasing treatment stability. Maintaining virologic suppression postpartum remains challenging despite advances in ART. Targeted postpartum strategies are needed to ensure durable virologic control.\n                  <\/jats:p>","DOI":"10.1177\/10872914261486529","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:10:16Z","timestamp":1789470616000},"page":"431-445","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Postpartum Virologic Failure Among Women with HIV Suppressed at Delivery in Spain: Incidence, Timing, and Associated Factors"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-4462","authenticated-orcid":false,"given":"Rebeca","family":"Izquierdo","sequence":"first","affiliation":[{"name":"CoRIS Cohort Coordination Unit, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain."},{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rava","sequence":"additional","affiliation":[{"name":"CoRIS Cohort Coordination Unit, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain."},{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Hernando","sequence":"additional","affiliation":[{"name":"CoRIS Cohort Coordination Unit, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain."},{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Su\u00e1rez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."},{"name":"Infectious Diseases Group, Department of Internal Medicine, Infanta Sof\u00eda University Hospital, Foundation for Biomedical Research and Innovation of Infanta Sof\u00eda and Henares University Hospitals (FIIB HUIS HHEN), Madrid, Spain."},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."},{"name":"Department of Internal Medicine, Elche General University Hospital, Elche, Spain."},{"name":"Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO), Valencia, Spain."},{"name":"Faculty of Medicine, Miguel Hern\u00e1ndez University, Alicante, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rivero","sequence":"additional","affiliation":[{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."},{"name":"Infectious Diseases Unit, Reina Sof\u00eda University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), C\u00f3rdoba, Spain."},{"name":"Department of Medicine, Faculty of Medicine and Nursing, University of C\u00f3rdoba, C\u00f3rdoba, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"G\u00fcerri-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."},{"name":"HIV-STD Division, Department of Internal Medicine, Group for Research in Viral Infections (GRIV), Hospital del Mar Research Institute, Barcelona, Spain."},{"name":"Department of Medicine and Life Sciences (MELIS), Pompeu Fabra University, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Rubio","sequence":"additional","affiliation":[{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."},{"name":"HIV Unit, Department of Internal Medicine, 12 de Octubre University Hospital, Health Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain."},{"name":"Department of Medicine, Complutense University of Madrid, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Garc\u00eda-Arriaza","sequence":"additional","affiliation":[{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."},{"name":"Department of Molecular and Cellular Biology, National Center for Biotechnology (CNB), Spanish National Research Council (CSIC), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Guti\u00e9rrez-Cuadra","sequence":"additional","affiliation":[{"name":"CIBERINFEC, Carlos III Health Institute, Madrid, Spain."},{"name":"Department of Infectious Diseases, Marqu\u00e9s de Valdecilla University Hospital\u2013IDIVAL, Santander, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, San Pedro University Hospital, Logro\u00f1o, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Palacios","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Virgen de la Victoria University Hospital\u2013IBIMA Plataforma BIONAND, M\u00e1laga, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Galindo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Valencia University Clinical Hospital, Valencia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7485-2252","authenticated-orcid":false,"given":"Inmaculada","family":"Jarr\u00edn","sequence":"additional","affiliation":[{"name":"CoRIS Cohort Coordination 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Ministerio de Sanidad: Madrid; 2025."}],"container-title":["AIDS Patient Care and STDs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10872914261486529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10872914261486529","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10872914261486529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:26:21Z","timestamp":1791379581000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10872914261486529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11,1]]}},"alternative-id":["10.1177\/10872914261486529"],"URL":"https:\/\/doi.org\/10.1177\/10872914261486529","relation":{},"ISSN":["1087-2914","1557-7449"],"issn-type":[{"value":"1087-2914","type":"print"},{"value":"1557-7449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]}}}