{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:15:13Z","timestamp":1777936513166,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Semin Cardiothorac Vasc Anesth"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Venous-arterial CO2 difference (Pv-aCO2) is a valuable marker that can identify a subset of patients in shock with inadequate cardiac output to meet tissue metabolic requirements. Some authors have found that Pv-aCO2 levels calculated from mixed vs central venous blood demonstrate a linear relationship. The purpose of this study is to determine whether there is a linear relationship between Pv-aCO2 obtained with peripheral venous blood (Pv-aCO2p) and with mixed venous blood, and the agreement between the 2 measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, single-center, observational clinical study enrolling mechanically ventilated patients in septic shock during the first 24\u00a0hours following admission to the intensive care unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Bravais\u2013Pearson r-coefficient between Pv-aCO2 and Pv-aCO2p was .70 in 38 determinations (95%CI .48-.83; P-value = 1.25 x 10^-6). The Bland\u2013Altman bias was 4.11\u00a0mmHg (95%CI 2.82\u20135.39), and the repeatability coefficient was 11.05. Using the Taffe approach, the differential and proportional biases were 2.81 (95%CI .52\u20135.11) and 1.29 (95%CI .86\u20131.72), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was linear correlation between Pv-aCO2p and Pv-aCO2 in mechanically ventilated patients with septic shock. The bias showed a gradual increase in high Pv-aCO2 values in an upward trend.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10892532231219917","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T05:30:05Z","timestamp":1701408605000},"page":"18-27","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlation and Agreement Between the CO2 Gap Obtained From Peripheral Venous Blood and From Mixed Venous Blood in Mechanically Ventilated Septic Patients"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7136-0343","authenticated-orcid":false,"given":"Daniele","family":"Orso","sequence":"first","affiliation":[{"name":"Anaesthesia and Intensive Care Medicine Department, ASUFC University Hospital of Udine and Department of Medical Science (DAME), University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Molinari","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Medicine Department, ASUFC University Hospital of Udine and Department of Medical Science (DAME), University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Bacchetti","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Medicine Department, ASUFC University Hospital of Udine and Department of Medical Science (DAME), University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Zanini","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Medicine Department, ASUFC University Hospital of Udine and Department of Medical Science (DAME), University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Montanar","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Medicine Department, ASUFC University Hospital of Udine and Department of Medical Science (DAME), University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Copetti","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Community Hospital of Latisana, Latisana, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Guglielmo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Community Hospital of Latisana, Latisana, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Bove","sequence":"additional","affiliation":[{"name":"Anaesthesia and Intensive Care Medicine Department, ASUFC University Hospital of Udine and Department 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