{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:15:18Z","timestamp":1777936518987,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Semin Cardiothorac Vasc Anesth"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    : Postoperative atrial fibrillation (POAF) occurs in 20%\u201340% of patients following coronary artery bypass grafting (CABG), contributing to significant morbidity. POAF is linked to elevated catecholamines, oxidative stress, and inflammatory mediators. Dexmedetomidine, a centrally acting alpha-2 agonist with sympatholytic and anti-inflammatory effects, and hydrocortisone, which suppresses inflammatory mediators, may reduce the incidence of POAF.\n                    <jats:bold>Methods<\/jats:bold>\n                    : A prospective, double-blind randomized controlled trial was conducted on 248 patients undergoing elective on-pump CABG at Ain Shams University Hospital. Patients were randomized into 2 groups: the Treatment Group received dexmedetomidine and hydrocortisone, and the Placebo Group received standard care. The primary endpoint was the occurrence of POAF within 7\u00a0days postoperatively.\n                    <jats:bold>Results<\/jats:bold>\n                    : All 248 patients (124 per group) completed the study. The combined use of dexmedetomidine and hydrocortisone reduced POAF incidence (4.8% vs 12.9%). ICU and hospital length of stay were also shorter in the Treatment Group (2.77 \u00b1 1.12 vs 3.16 \u00b1 1.34\u00a0days,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .012, and 6.63 \u00b1 1.56 vs 7.11 \u00b1 2\u00a0days,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .035, respectively). No differences in hypotension, bradycardia, or wound infections were observed. Hyperglycemia, defined as blood glucose &gt;180\u00a0mg\/dl, occurred in 8.1% of the Treatment Group and 6.5% of the Placebo Group.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Combining dexmedetomidine and hydrocortisone effectively reduces POAF incidence after CABG, with manageable side effects. Multicenter trials are warranted to confirm these findings.\n                    <jats:italic toggle=\"yes\">Date and Number of IRB Approval and Clinical Trial Registry Number<\/jats:italic>\n                    . Ain Shams University Protocol Record (FMASU R 261\/2022),\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    Identifier: NCT05674253.\n                  <\/jats:p>","DOI":"10.1177\/10892532251338374","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T01:36:06Z","timestamp":1745804166000},"page":"284-290","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Combined Use of Dexmedetomidine and Hydrocortisone to Prevent New-Onset Atrial Fibrillation After Coronary Artery Bypass Grafting Surgery: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6430-4332","authenticated-orcid":false,"given":"Mohamed Alaaeldin","family":"Alhadidy","sequence":"first","affiliation":[{"name":"Ain Shams University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel Mohamed","family":"Alansary","sequence":"additional","affiliation":[{"name":"Ain Shams University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-509X","authenticated-orcid":false,"given":"Sarah Hamdy","family":"Elghareeb","sequence":"additional","affiliation":[{"name":"Ain Shams University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"e_1_3_7_2_2","first-page":"110","volume-title":"Use of Magnesium to Decrease Postoperative Risk of Arrhythmias in Patients Undergoing Coronary Artery Bypass Graft Surgery: An Educational Module","author":"Huynh H","unstructured":"Huynh H. Use of Magnesium to Decrease Postoperative Risk of Arrhythmias in Patients Undergoing Coronary Artery Bypass Graft Surgery: An Educational Module. Nicole Wertheim College of Nursing Student Projects; 2022:110. https:\/\/digitalcommons.fiu.edu\/cnhs-studentprojects\/110."},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx039"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.03.011"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-015-0092-5"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0419-5"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12636"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12062"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000070"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.10.025"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn333"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.848218"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-021-02167-z"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsha.2016.03.005"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000665"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.14.1562"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad019"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1480-5"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.721264"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2010.512609"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025130"}],"container-title":["Seminars in Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10892532251338374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10892532251338374","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10892532251338374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:34:57Z","timestamp":1777692897000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10892532251338374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,27]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/10892532251338374"],"URL":"https:\/\/doi.org\/10.1177\/10892532251338374","relation":{},"ISSN":["1089-2532","1940-5596"],"issn-type":[{"value":"1089-2532","type":"print"},{"value":"1940-5596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,27]]}}}