{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:15:19Z","timestamp":1777936519601,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Semin Cardiothorac Vasc Anesth"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Dexmedetomidine, a highly selective \u03b12-adrenergic receptor agonist, may help mitigate postoperative complications in patients undergoing aortic vascular surgery.\n                    <jats:bold>Methodology:<\/jats:bold>\n                    A comprehensive search was conducted across PubMed, the Cochrane Library, and Embase to identify studies assessing the efficacy and safety of dexmedetomidine compared with placebo in patients undergoing aortic vascular surgery. A random effects meta-analysis was performed with R version 4.4.1 using the \u201cmeta\u201d package.\n                    <jats:bold>Results:<\/jats:bold>\n                    Our analysis included eleven studies, comprising eight RCTs and three cohort studies, with a combined total of 1731 patients. The results showed that dexmedetomidine significantly reduced acute kidney injury (OR 0.49, 95% CI 0.25 to 0.98), ICU length of stay (MD \u22120.25\u00a0days, 95% CI \u22120.47 to \u22120.02), postoperative pulmonary complications (OR 0.55, 95% CI 0.32 to 0.94), and CRP levels 24\u00a0h post-surgery (MD \u221224.73\u00a0mg\/L, 95% CI \u221246.29 to \u22123.16) compared to the control group. The length of hospital stay (MD -0.87 days, 95% CI \u22122.57 to 1.01), postoperative delirium (OR 0.78, 95% CI 0.43 to 1.42), and in-hospital mortality (OR 0.57, 95% CI 0.29 to 1.12) were not significantly different between the two groups.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    In patients undergoing aortic vascular surgery, dexmedetomidine administration is associated with reduced acute kidney injury, length of ICU stay, postoperative pulmonary complications, and CRP levels 24\u00a0h post-surgery.\n                  <\/jats:p>","DOI":"10.1177\/10892532251346645","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T23:57:29Z","timestamp":1750895849000},"page":"291-299","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Dexmedetomidine on Acute Kidney Injury and Perioperative Outcomes in Aortic Vascular Surgery: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6355-3907","authenticated-orcid":false,"given":"Tallal Mushtaq","family":"Hashmi","sequence":"first","affiliation":[{"name":"Rawalpindi Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadiah","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Burhan","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohma","family":"Zia","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mushood","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Imperial College London, UK"},{"name":"Department of Cardiology, Royal Brompton Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid Toseef","family":"Aized","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, North Alabama Medical Center"},{"name":"Kentucky College of Osteopathic Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2022.2718"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1532\/hsf.5025"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.788645"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.191570"},{"issue":"3","key":"e_1_3_5_6_2","first-page":"CD004476","article-title":"Perioperative beta-blockers for preventing surgery-related mortality and morbidity","volume":"3","author":"Blessberger H","year":"2018","unstructured":"Blessberger H, Kammler J, Domanovits H, et al. Perioperative beta-blockers for preventing surgery-related mortality and morbidity. 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