{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:38:51Z","timestamp":1792604331655,"version":"4.5.0"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Semin Cardiothorac Vasc Anesth"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Vasopressor choice potentially contributes to postoperative delirium due to differences in end-organ perfusion. This study seeks to determine the rates of postoperative delirium after perioperative phenylephrine, ephedrine, or norepinephrine administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective, propensity-score matched multicenter database study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients aged 60 and older undergoing surgery of the integumentary, musculoskeletal, respiratory, hematologic\/lymphatic, gastrointestinal, genitourinary\/reproductive, endocrine, or sensory organ systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Perioperative vasopressor administration (phenylephrine, ephedrine, norepinephrine).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      The primary outcome was the incidence of postoperative delirium based on ICD-10 diagnostic codes within seven days of surgery. After propensity score matching, there was no difference in the rate of postoperative delirium between phenylephrine and norepinephrine (OR 0.97; 95% CI 0.61\u20131.54;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .9065) or between ephedrine and norepinephrine (OR 0.74; 95% CI 0.41-1.32;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .3062). Phenylephrine was associated with a higher rate of postoperative delirium when compared to ephedrine (OR 1.30; 95% CI 1.05\u20131.60;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .0162), although absolute risk difference was small (0.05%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the potential influence of vasopressor selection on postoperative neurocognitive outcomes in older adults. Understanding the physiologic and pharmacologic mechanisms underlying these associations may help guide individualized intraoperative management and reduce delirium risk in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10892532261465066","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:47:52Z","timestamp":1782474472000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Vasopressor Selection and Postoperative Delirium in Older Adults: A Propensity-Matched Database Analysis"],"prefix":"10.1177","author":[{"given":"Tiffany","family":"Dong","sequence":"first","affiliation":[{"name":"University of California Riverside"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Mao","sequence":"additional","affiliation":[{"name":"University of California Riverside"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Baker","sequence":"additional","affiliation":[{"name":"Riverside University Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9570-1944","authenticated-orcid":false,"given":"Blake","family":"Han","sequence":"additional","affiliation":[{"name":"Riverside University Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard J.","family":"Soloniuk","sequence":"additional","affiliation":[{"name":"Riverside University Health System"},{"name":"Riverside University Health System"},{"name":"Loma Linda University"},{"name":"Loma Linda University"},{"name":"University of California Riverside"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Stier","sequence":"additional","affiliation":[{"name":"Riverside University Health System"},{"name":"Loma Linda University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Novak","sequence":"additional","affiliation":[{"name":"University of California Riverside"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Pasca","sequence":"additional","affiliation":[{"name":"University of California Riverside"},{"name":"Riverside University Health System"},{"name":"Loma Linda University"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-8400","authenticated-orcid":false,"given":"Jiapeng","family":"Huang","sequence":"additional","affiliation":[{"name":"University of Louisville"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.07.021"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.005"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005739"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001352"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-68273-2"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004774"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2012.00345.x"},{"key":"e_1_3_6_9_2","first-page":"e79626","article-title":"Comparison of ephedrine vs. norepinephrine in treating anesthesia-induced hypotension in hypertensive patients: randomized double-blinded study","volume":"8","author":"Hassani V","year":"2018","unstructured":"Hassani V, Movaseghi G, Safaeeyan R, Masghati S, Ghorbani Yekta B, Farahmand RR. 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