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Additional mortality data show that the rate of drug overdose deaths in Florida is 12.5% higher than the suicide death rate. Some have hypothesized that economic social determinants of health (SDH) may be responsible for the recent increase in DOD. The current study, using secondary data, sought to identify what county-level SDH were significantly associated with county-level DOD. Using backward regression methodology, the results of the analysis indicate that 44% of the variance in county-level DOD is significantly associated with six county-level SDH: (a) Recent Medical Checkup, (b) Income, (c) Education Level, (d) Age, (e) Mental Health Professionals, and (f) the Income \u00d7 Age interaction term. Higher than average income, age, and mental health professionals in a Florida county was associated with significantly higher rates of DOD. Higher than average levels of education and recent checkups in a Florida county were associated with a significant decrease in DOD. Possible explanations and implications are discussed.<\/jats:p>","DOI":"10.1177\/1090198118811888","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T02:02:28Z","timestamp":1542938548000},"page":"329-339","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Deaths of Despair in Florida: Assessing the Role of Social Determinants of Health"],"prefix":"10.1177","volume":"46","author":[{"given":"Robert J.","family":"Zeglin","sequence":"first","affiliation":[{"name":"The University of North Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle R. 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