{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:40:07Z","timestamp":1785498007035,"version":"3.56.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Suction drains are commonly placed after rhytidectomy surgery to avoid seroma formation that may result from dead spaces between skin layers. Fibrin sealants promote tissue adherence by cross-linking with extracellular matrix proteins, which may reduce the dead space under skin flaps.<\/jats:p>\n                  <jats:p>Objectives: The authors evaluate the safety and preliminary efficacy of the fibrin sealant (FS) VH S\/D 4 s-apr (ARTISS; Baxter Healthcare Corp, Deerfield, Illinois), added to standard-of-care (SoC) treatment, on tissue plane adherence and local hemostasis in rhytidectomy patients.<\/jats:p>\n                  <jats:p>Methods: In this phase 2, prospective, controlled, randomized, evaluator- and patient-blinded, multicenter study, 45 patients (of 56 possible enrollees) received SoC treatment on 1 side of the face and adjunctive FS VH S\/D 4 s-apr treatment on the other side. Outcomes measures included visual assessments of ecchymosis (by blinded reviewers), grading of ecchymosis and edema, drainage volumes, occurrence of hematoma\/seroma, safety evaluations, and patient-reported assessments of pain, numbness, and treatment preferences postoperatively.<\/jats:p>\n                  <jats:p>Results: Mean patient age was 55.1 years. Rates and grades of ecchymosis and edema were similar for the 2 treatments. The mean (SD) drainage volume 24 hours after surgery was 11.5 (13.7) mL from the FS VH S\/D 4 s-apr\u2013treated sides of the face and 26.8 (24.0) mL from the SoC-only sides (P &amp;lt; .0001). Patient assessments of pain, numbness, and preference favored treatment with FS VH S\/D 4 s-apr. Adverse events were mild to moderate in severity.<\/jats:p>\n                  <jats:p>Conclusions: Adjuvant use of FS VH S\/D 4 s-apr appears to be safe and results in lower drainage volumes than SoC treatment alone.<\/jats:p>\n                  <jats:p>Level of Evidence: 2<\/jats:p>\n                  <jats:p\/>","DOI":"10.1177\/1090820x13477860","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T17:38:23Z","timestamp":1363801103000},"page":"323-333","source":"Crossref","is-referenced-by-count":30,"title":["Exploratory, Randomized, Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of Adjuvant Fibrin Sealant VH S\/D 4 S-Apr (ARTISS) in Patients Undergoing Rhytidectomy"],"prefix":"10.1093","volume":"33","author":[{"suffix":"Jr.","given":"T. Roderick","family":"Hester","sequence":"first","affiliation":[{"name":"Dr Hester is a plastic surgeon in private practice in Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary E.","family":"Gerut","sequence":"additional","affiliation":[{"name":"Dr Gerut is a plastic surgeon in private practice in Hewlett, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Shire","sequence":"additional","affiliation":[{"name":"Dr Shire is a plastic surgeon in private practice in Chattanooga, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis B.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Dr Nguyen is a plastic surgeon in private practice in Beverly Hills, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achih H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Dr Chen is a plastic surgeon in private practice in Evans, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Diamond","sequence":"additional","affiliation":[{"name":"Dr Chen is a plastic surgeon in private practice in Evans, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian C.","family":"Desmond","sequence":"additional","affiliation":[{"name":"Dr Desmond is a Senior Manager of Clinical Development"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Silvati-Fidell","sequence":"additional","affiliation":[{"name":"Ms Silvati-Fidell is a Senior Biostatistician"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve Zvi","family":"Abrams","sequence":"additional","affiliation":[{"name":"Dr Abrams is a Medical Director at Baxter Healthcare Corporation in Westlake Village, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"2025110820003327200_bibr1-1090820X13477860","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0094-1298(20)30962-7","article-title":"An historical glimpse of the evolution of rhytidectomy","volume":"22","author":"Larson","year":"1995","journal-title":"Clin Plast Surg."},{"key":"2025110820003327200_bibr2-1090820X13477860","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1001\/archotol.1997.01900070087014","article-title":"Prevention of seromas and hematomas after face-lift surgery with the use of postoperative vacuum drains","volume":"123","author":"Perkins","year":"1997","journal-title":"Arch Otolaryngol Head Neck Surg."},{"key":"2025110820003327200_bibr3-1090820X13477860","first-page":"1581","article-title":"The current status of tissue glues, part II: for adhesion of soft tissues","volume":"110","author":"Gosain","year":"2002","journal-title":"Plast Reconstr Surg."},{"issue":"3","key":"2025110820003327200_bibr4-1090820X13477860","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/00006534-197903000-00005","article-title":"Why do skin grafts fail?","volume":"63","author":"Teh","year":"1979","journal-title":"Plast Reconstr Surg."},{"issue":"2","key":"2025110820003327200_bibr5-1090820X13477860","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00006534-199202000-00011","article-title":"The effect of fibrin glue on skin grafts in infected sites","volume":"89","author":"Jabs","year":"1992","journal-title":"Plast Reconstr Surg."},{"key":"2025110820003327200_bibr6-1090820X13477860","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0007-1226(94)90087-6","article-title":"Face lifts and sprayed fibrin glue: an outcome analysis of 200 patients","volume":"47","author":"Marchac","year":"1994","journal-title":"Br J Plast Surg."},{"key":"2025110820003327200_bibr7-1090820X13477860","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/00006534-200208000-00044","article-title":"The use of aerosolized fibrin glue in face-lift surgery","volume":"110","author":"Fezza","year":"2002","journal-title":"Plast Reconstr Surg."},{"key":"2025110820003327200_bibr8-1090820X13477860","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00266-008-9280-1","article-title":"Use of tissue sealants in face-lifts: a metaanalysis","volume":"33","author":"Por","year":"2009","journal-title":"Aesthetic Plast Surg."},{"key":"2025110820003327200_bibr9-1090820X13477860","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1097\/01.PRS.0000153219.32665.D5","article-title":"Early postoperative efficacy of fibrin glue in face lifts: a prospective randomized trial","volume":"115","author":"Marchac","year":"2005","journal-title":"Plast Reconstr Surg."},{"issue":"1","key":"2025110820003327200_bibr10-1090820X13477860","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/01.PRS.0000097291.15196.78","article-title":"Avoiding hematoma in cervicofacial rhytidectomy: a personal 8-year quest. Reviewing 910 patients","volume":"113","author":"Jones","year":"2004","journal-title":"Plast Reconstr Surg."},{"key":"2025110820003327200_bibr11-1090820X13477860","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/BCR.0b013e31816673f8","article-title":"Efficacy and safety of a fibrin sealant for adherence of autologous skin grafts to burn wounds: results of a phase 3 clinical study","volume":"29","author":"Foster","year":"2008","journal-title":"J Burn Care Res."},{"issue":"3","key":"2025110820003327200_bibr12-1090820X13477860","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/BCR.0B013E318053D389","article-title":"Comparison of fibrin sealant and staples for attaching split-thickness autologous sheet grafts in patients with deep partial- or full-thickness burn wounds: a phase 1\/2 clinical study","volume":"28","author":"Gibran","year":"2007","journal-title":"J Burn Care Res."},{"issue":"6","key":"2025110820003327200_bibr13-1090820X13477860","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.asj.2003.09.010","article-title":"In vivo use of human fibrin glue under the subperiosteal and subcutaneous planes in Holtzman rats","volume":"23","author":"Sasaki","year":"2003","journal-title":"Aesthetic Surg J."},{"key":"2025110820003327200_bibr14-1090820X13477860","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/01.prs.0000278092.28351.c9","article-title":"Experience with fibrin glue in rhytidectomy","volume":"120","author":"Kamer","year":"2007","journal-title":"Plast Reconstr Surg."},{"key":"2025110820003327200_bibr15-1090820X13477860","first-page":"360","article-title":"Understanding interobserver agreement: the kappa statistic","volume":"37","author":"Viera","year":"2005","journal-title":"Fam Med."},{"key":"2025110820003327200_bibr16-1090820X13477860","article-title":"Randomized, controlled phase 3 study to evaluate safety and efficacy of Fibrin Sealant (FS) VH S\/D 4 s-apr (ARTISS) to improve tissue adherence in patients undergoing rhytidectomy","author":"Hester","journal-title":"Aesthetic Surg J."},{"key":"2025110820003327200_bibr17-1090820X13477860","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/01.prs.0000232224.75241.8b","article-title":"Platelet gel sealant use in rhytidectomy","volume":"118","author":"Brown","year":"2006","journal-title":"Plast Reconstr Surg."},{"key":"2025110820003327200_bibr18-1090820X13477860","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1097\/01.prs.0000191182.70617.e9","article-title":"Reducing the incidence of hematoma requiring surgical evacuation following male rhytidectomy: a 30-year review of 985 cases","volume":"116","author":"Baker","year":"2005","journal-title":"Plast Reconstr Surg."},{"key":"2025110820003327200_bibr19-1090820X13477860","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/j.joms.2006.10.075","article-title":"Complications after superficial plane cervicofacial rhytidectomy: a retrospective analysis of 178 consecutive facelifts and review of the literature","volume":"65","author":"Griffin","year":"2007","journal-title":"J Oral Maxillofac Surg."}],"container-title":["Aesthetic Surgery Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/33\/3\/323\/6046913\/33-3-323.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/asj\/article-pdf\/33\/3\/323\/6046913\/33-3-323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T01:00:39Z","timestamp":1762650039000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/asj\/article\/33\/3\/323\/297329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,1]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,1]]},"published-print":{"date-parts":[[2013,3,1]]}},"URL":"https:\/\/doi.org\/10.1177\/1090820x13477860","relation":{},"ISSN":["1527-330X","1090-820X"],"issn-type":[{"value":"1527-330X","type":"electronic"},{"value":"1090-820X","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,3]]},"published":{"date-parts":[[2013,3,1]]}}}