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Quaternium-15 was an oral teratogen, but not a dermal teratogen, in rats at doses that exceeded the expected cumulative exposure from cosmetics. The frequency of sensitization increased in North America but not in Europe, where Quaternium-15 is used less often. In almost all animal and human studies, Quaternium-15 at 0.2% was not a sensitizer. The weight of evidence suggested that a 0.2% concentration is not a sensitizer and that cosmetic products containing Quaternium-15 up to that level are safe.<\/jats:p>","DOI":"10.1177\/1091581810363915","type":"journal-article","created":{"date-parts":[[2010,5,6]],"date-time":"2010-05-06T19:28:21Z","timestamp":1273174101000},"page":"98S-114S","source":"Crossref","is-referenced-by-count":9,"title":["Final Report of the Amended Safety Assessment of Quaternium-15 as Used in Cosmetics"],"prefix":"10.1177","volume":"29","author":[{"given":"Lillian C.","family":"Becker","sequence":"first","affiliation":[{"name":"Cosmetic Ingredient Review , cirinfo@cir-safety.org"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma F.","family":"Bergfeld","sequence":"additional","affiliation":[{"name":"Cosmetic Ingredient Review"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald V.","family":"Belsito","sequence":"additional","affiliation":[{"name":"Cosmetic Ingredient Review"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis D.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Cosmetic Ingredient Review"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Hill","sequence":"additional","affiliation":[{"name":"Cosmetic Ingredient Review"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Leibler","sequence":"additional","affiliation":[{"name":"Cosmetic Ingredient Review"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Marks","sequence":"additional","affiliation":[{"name":"Cosmetic Ingredient Review"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Shank","sequence":"additional","affiliation":[{"name":"Cosmetic Ingredient Review"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Slaga","sequence":"additional","affiliation":[{"name":"Cosmetic Ingredient Review"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Cosmetic Ingredient Review"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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