{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:29:24Z","timestamp":1777717764907,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Toxicol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>\n                    This investigation was aimed to study the effect of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on mercuric chloride (HgCl\n                    <jats:sub>2<\/jats:sub>\n                    )-induced alterations in urinary excretion of various carnitine fractions including free carnitine (FC), acylcarnitine (AC), and total carnitine (TC). Different groups of Wistar male rats were treated with HgCl\n                    <jats:sub>2<\/jats:sub>\n                    at the doses of 0.1, 0.5, 1.0, 2.0, and 3.0 mg\/kg body weight, and the animals were sacrificed at 24 hours following HgCl\n                    <jats:sub>2<\/jats:sub>\n                    injection. A separate batch of animals received HgCl\n                    <jats:sub>2<\/jats:sub>\n                    (2 mg\/kg) with or without DMPS (100 mg\/kg) and sacrificed at 24 or 48 hours after dosing. Administration of HgCl\n                    <jats:sub>2<\/jats:sub>\n                    resulted in statistically significant and dose-dependent increase in the urinary excretion of FC, AC, and TC in rats. However, the ratio of urinary AC:FC was significantly decreased by HgCl\n                    <jats:sub>2<\/jats:sub>\n                    . Pretreatment with DMPS offered statistically significant protection against HgCl\n                    <jats:sub>2<\/jats:sub>\n                    -induced alterations in various urinary carnitine fractions in rats.\n                  <\/jats:p>","DOI":"10.1177\/1091581810364852","type":"journal-article","created":{"date-parts":[[2010,5,6]],"date-time":"2010-05-06T19:38:28Z","timestamp":1273174708000},"page":"313-317","source":"Crossref","is-referenced-by-count":1,"title":["Increased Urinary Excretion of Carnitine and Acylcarnitine by Mercuric Chloride Is Reversed by 2,3-Dimercapto-1-Propanesulfonic Acid in Rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Waleed A.","family":"Al-Madani","sequence":"first","affiliation":[{"name":"Depatment of Pathology, Armed Forces Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhat J.","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of 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