{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:34:04Z","timestamp":1777718044378,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Toxicol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>The fragrance ingredient 4- tert-butylcyclohexyl acetate (4- tBCHA) was evaluated for potential developmental toxicity in pregnant rats at oral dosages of 0, 40, 160, or 640 mg\/kg per d in corn oil on gestational days 7 to 20. Increased salivation was observed at 160 and 640 mg\/kg per d. The 640 mg\/kg per d dosage was associated with the presence of a red perioral substance, ungroomed, sparse hair coat on the limbs, localized alopecia, reduced feed and body weight gains, or body weight losses, and mortality. Fetal body weights also were reduced at 640 mg\/kg per d. This effect was associated with transient delays in fetal development, including significant increases in fetal incidences of moderate enlargement of the renal pelvis and reversible delays in ossification of the caudal vertebrae, fore and hind limb phalanges, and hind limb metatarsals. Maternal and developmental no observable adverse effect levels (NOAELs) were 160 mg\/kg per d. It was concluded that 4- tBCHA is not a developmental toxicant in rats.<\/jats:p>","DOI":"10.1177\/1091581812460865","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T13:32:51Z","timestamp":1349962371000},"page":"477-482","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Developmental Toxicity of 4-\n                    <i>Tert<\/i>\n                    -Butylcyclohexyl Acetate in Sprague-Dawley Rats"],"prefix":"10.1177","volume":"31","author":[{"given":"Valerie T.","family":"Politano","sequence":"first","affiliation":[{"name":"Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"McGinty","sequence":"additional","affiliation":[{"name":"Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Charles River Laboratories Preclinical Services, Horsham, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan M.","family":"Hoberman","sequence":"additional","affiliation":[{"name":"Charles River Laboratories Preclinical Services, Horsham, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Diener","sequence":"additional","affiliation":[{"name":"Argus International, Inc., Horsham, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Marie","family":"Api","sequence":"additional","affiliation":[{"name":"Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,11]]},"reference":[{"key":"bibr1-1091581812460865","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.09.038"},{"key":"bibr2-1091581812460865","unstructured":"IFRA. 2008 Volume of use survey. International Fragrance Association; 2008. www.ifraorg.org. Accessed May 29, 2012."},{"key":"bibr3-1091581812460865","unstructured":"IFRA. 2008 Fragrance use level survey. International Fragrance Association; 2008. www.ifraorg.org. Accessed May 29, 2012."},{"key":"bibr4-1091581812460865","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1999.1362"},{"key":"bibr5-1091581812460865","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2002.1581"},{"issue":"12","key":"bibr6-1091581812460865","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.fct.2008.09.039","volume":"46","author":"Belsito D","year":"2008","journal-title":"Food Chem Toxicol"},{"issue":"22","key":"bibr7-1091581812460865","volume":"59","author":"FDA","year":"1994","journal-title":"US Food and Drug Administration: Federal Register"},{"key":"bibr8-1091581812460865","author":"FDA","year":"1987","journal-title":"U.S. Food and Drug Administration"},{"issue":"26","key":"bibr9-1091581812460865","volume-title":"Good Laboratory Practice Standard for Safety Studies on Drugs","volume":"21","author":"MHW","year":"1997"},{"key":"bibr10-1091581812460865","doi-asserted-by":"publisher","DOI":"10.1787\/9789264078536-en"},{"key":"bibr11-1091581812460865","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Institute of Laboratory Animal Resources","year":"1996"},{"key":"bibr12-1091581812460865","first-page":"262","volume-title":"Teratology: Principles and Techniques","author":"Wilson JG.","year":"1965"},{"key":"bibr13-1091581812460865","first-page":"61","volume":"39","author":"Staples RE","year":"1964","journal-title":"Stain Technol"},{"key":"bibr14-1091581812460865","first-page":"240","volume-title":"Statistical Methods","author":"Snedecor GW","year":"1967","edition":"6"},{"key":"bibr15-1091581812460865","unstructured":"Sokal RR, Rohlf FJ. Bartlett\u2019s test of homogeneity of variances. Biometry: the Principles and Practice of Statistics in Biological Research. San Francisco, CA: W.H. Freeman and Co; 1969:370\u2013371."},{"key":"bibr16-1091581812460865","unstructured":"Snedecor GW, Cochran WG. Analysis of variance. Statistical Methods. 6th ed. Ames: Iowa State University Press; 1967:258\u2013298."},{"key":"bibr17-1091581812460865","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1955.10501294"},{"key":"bibr18-1091581812460865","doi-asserted-by":"crossref","unstructured":"Sokal RR, Rohlf FJ. Kruskal-Wallis test. Biometry: the Principles and Practice of Statistics in Biological Research. San Francisco, CA: W.H. Freeman and Co. 1969:388\u2013391.","DOI":"10.2307\/2412280"},{"key":"bibr19-1091581812460865","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1964.10490181"},{"key":"bibr20-1091581812460865","volume-title":"Nonparametric Statistics for the Behavioral Sciences","author":"Siegel S","year":"1956"},{"key":"bibr21-1091581812460865","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/58.1.1"},{"key":"bibr22-1091581812460865","volume-title":"Rabbit covered patch skin irritation test with 4-tert-butylcyclohexyl acetate","author":"RIFM"},{"key":"bibr23-1091581812460865","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(87)90098-6"},{"key":"bibr24-1091581812460865","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420060210"}],"container-title":["International Journal of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1091581812460865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1091581812460865","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1091581812460865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:24:05Z","timestamp":1777458245000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1091581812460865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1177\/1091581812460865"],"URL":"https:\/\/doi.org\/10.1177\/1091581812460865","relation":{},"ISSN":["1091-5818","1092-874X"],"issn-type":[{"value":"1091-5818","type":"print"},{"value":"1092-874X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}