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Steatosis is of critical importance because prevention of fatty liver can obviate downstream pathologies of liver disease (eg, fibrosis). Recent studies have shown a strong correlation between chemical exposure and steatosis. The work described here identifies chemicals on the US Environmental Protection Agency\u2019s Integrated Risk Information System (IRIS) that induce steatosis and investigates putative mechanisms by which these chemicals may contribute to this pathological condition. Mitochondrial impairment, insulin resistance, impaired hepatic lipid secretion, and enhanced cytokine production were identified as potential mechanisms that could contribute to steatosis. Taken together, this work is significant because it identifies multiple mechanisms by which environmental chemicals may cause fatty liver and expands our knowledge of the possible role of environmental chemical exposure in the induction and progression of liver disease.<\/jats:p>","DOI":"10.1177\/1091581812466418","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T01:59:02Z","timestamp":1354240742000},"page":"551-563","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Putative Mechanisms of Environmental Chemical\u2013Induced Steatosis"],"prefix":"10.1177","volume":"31","author":[{"given":"J. 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