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Jurkat T cells were exposed to the solvents individually for 72 hours and changes in reactive oxygen species (ROS) formation, cell proliferation, intracellular free calcium concentration ([Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]), and caspase-3 activity were measured. There was a concentration-dependent increase in the ROS formation and intracellular free [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ] following exposure to each of the solvents. This was accompanied by a decrease in the cell proliferation. Solvent potency decreased in the following order: PERC &gt; TCE &gt; DCM &gt; DCE. Caspase-3 activity was increased in a concentration-dependent manner by TCE and PERC but was not significantly altered by DCM or DCE. n-Acetyl-l-cysteine pretreatment showed that changes in the intracellular free [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ] and caspase-3 activity were independent of ROS formation. 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