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No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 \u03bcg of extract\/plate (Ames test) or 5000 \u03bcg of extract\/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg\/kg body weight (bw)\/d). The no observed effect level for CFE in this study was considered to be 1000 mg\/kg bw\/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg\/kg bw\/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.<\/jats:p>","DOI":"10.1177\/1091581813492827","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T21:35:47Z","timestamp":1371245747000},"page":"385-394","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Safety Assessment of a Hydroethanolic Extract of\n                    <i>Caralluma fimbriata<\/i>"],"prefix":"10.1177","volume":"32","author":[{"given":"Antoinette Y.","family":"Odendaal","sequence":"first","affiliation":[{"name":"AIBMR Life Sciences, Inc, Puyallup, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra S.","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"INTOX Pvt Ltd, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tennille K.","family":"Marx","sequence":"additional","affiliation":[{"name":"AIBMR Life Sciences, Inc, Puyallup, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Schauss","sequence":"additional","affiliation":[{"name":"AIBMR Life Sciences, Inc, Puyallup, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Endres","sequence":"additional","affiliation":[{"name":"AIBMR Life Sciences, Inc, Puyallup, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Clewell","sequence":"additional","affiliation":[{"name":"AIBMR Life Sciences, Inc, Puyallup, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"bibr1-1091581813492827","volume-title":"Reviews on Indian Medicinal Plants (Ca-Ce)","volume":"5","author":"Gupta AK","year":"2007"},{"key":"bibr2-1091581813492827","volume-title":"The Wealth of India: A Dictionary of Indian Raw Materials & Industrial Products: Raw Materials","volume":"3","author":"Ambasta SSP","year":"1993"},{"key":"bibr3-1091581813492827","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2010.1555"},{"key":"bibr4-1091581813492827","doi-asserted-by":"crossref","unstructured":"Albers F, Meve U. editors. 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