{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T11:28:06Z","timestamp":1779017286132,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Toxicol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    The highly conserved human and mouse SLC39A8 gene encodes the divalent cation\/bicarbonate symporter ZIP8 expressed ubiquitously in most cell types. Our bacterial artificial chromosome-transgenic BTZIP8-3 line has 3 additional copies of the Slc39a8 gene in addition to its constitutive diploid pair found in wild-type (WT) mice. In liver, kidney, lung, testis, gastrointestinal tract, and brain, BTZIP8-3 mice are known to express \u223c2.5 times greater amounts of ZIP8, compared with WT mice. Herein we administered cadmium chloride (CdCl\n                    <jats:sub>2<\/jats:sub>\n                    ) in drinking water (100 mg\/L through week 2, 200 mg\/L through week 4, 400 mg\/L through week 8, 800 mg\/L through week 12, and 1600 mg\/L through week 20, when the experiment was concluded). We postulated that Cd uptake and distribution\u2013\u2013and, therefore, toxicity in certain tissues\u2013\u2013would be enhanced in BTZIP8-3, compared with WT mice. BTZIP8-3 and WT groups ingested comparable amounts of Cd. Compared with WT, BTZIP8-3 mice showed tissue specific: increases in Cd, zinc, and manganese content and decreases in calcium content. Both Cd-exposed BTZIP8-3 and WT were similar in lower urinary pH; increased plasma alanine and aspartate aminotransferase activities; elevated iron and copper content in liver, kidney, lung, and testis; and higher blood urea nitrogen and kidney weight. Histological changes in liver, kidney, lung, and testis were minimal. In summary, at the daily oral Cd exposures chosen for this study, 5 versus 2 Slc39a8 gene copies result in no differences in Cd toxicity but do cause differences in tissue-specific content of Cd, zinc, manganese, calcium, iron, and copper.\n                  <\/jats:p>","DOI":"10.1177\/1091581813513530","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T23:08:05Z","timestamp":1387321685000},"page":"14-20","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Oral Cadmium in Mice Carrying 5 Versus 2 Copies of the\n                    <i>Slc39a8<\/i>\n                    Gene"],"prefix":"10.1177","volume":"33","author":[{"given":"Scott N.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott E.","family":"Afton","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cincinnati School of Arts and Sciences, Cincinnati, OH, USA"},{"name":"Molecular Structure & Spectroscopy, Catalent Pharma Solutions, Morrisville, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoocher","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and Hypertension, University Cincinnati Medical Center, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Nebert","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,12,17]]},"reference":[{"key":"bibr1-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(97)00090-2"},{"key":"bibr2-1091581813513530","volume-title":"Priority List for Hazardous Substances","author":"ATSDR","year":"2011"},{"key":"bibr3-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldg032"},{"key":"bibr4-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.02.017"},{"key":"bibr5-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2003.07.011"},{"key":"bibr6-1091581813513530","unstructured":"Swedish Chemical Agency Report. Economic cost of fractures caused by dietary cadmium exposure; 2013. http:\/\/www.kemi.se\/Documents\/Publikationer\/Trycksaker\/Rapporter\/Rapport-4-13-cadmium.pdf."},{"key":"bibr7-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406085102"},{"key":"bibr8-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.024521"},{"key":"bibr9-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.367284"},{"key":"bibr10-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036055"},{"key":"bibr11-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1039\/c2mt20177a"},{"key":"bibr12-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00409.2006"},{"key":"bibr13-1091581813513530","first-page":"107","volume-title":"Casarett and Doull's Toxicology: The Basic Science of Poisons","author":"Rozman KK","year":"2007"},{"issue":"34","key":"bibr14-1091581813513530","volume":"25","author":"Gibey R","journal-title":"Clin Chim Acta"},{"key":"bibr15-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.09.025"},{"key":"bibr16-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-010-9328-y"},{"key":"bibr17-1091581813513530","volume-title":"Public Health Statement for Cadmium","author":"ATSDR","year":"2012"},{"key":"bibr18-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(86)80002-0"},{"key":"bibr19-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.11.021"},{"key":"bibr20-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.179"},{"key":"bibr21-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(02)00021-2"},{"key":"bibr22-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-010-9309-1"},{"key":"bibr23-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1306.011"},{"key":"bibr24-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(02)00078-9"},{"issue":"5","key":"bibr25-1091581813513530","first-page":"1413","volume":"73","author":"Girijashanker K","year":"2008","journal-title":"Slc39a14"},{"key":"bibr26-1091581813513530","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-012-9526-x"}],"container-title":["International Journal of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1091581813513530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1091581813513530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1091581813513530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:24:22Z","timestamp":1777458262000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1091581813513530"}},"subtitle":["Comparison of Uptake, Distribution, Metal Content, and Toxicity"],"short-title":[],"issued":{"date-parts":[[2013,12,17]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1177\/1091581813513530"],"URL":"https:\/\/doi.org\/10.1177\/1091581813513530","relation":{},"ISSN":["1091-5818","1092-874X"],"issn-type":[{"value":"1091-5818","type":"print"},{"value":"1092-874X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,17]]}}}