{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:36:08Z","timestamp":1777718168114,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Toxicol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>\n                    Mouse Slc39a8 and Slc39a14 genes encode ZIP8 and ZIP14, respectively, which are ubiquitous divalent cation\/(HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2013<\/jats:sup>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    symporters responsible for uptake of Zn\n                    <jats:sup>2+<\/jats:sup>\n                    , Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , and Mn\n                    <jats:sup>2+<\/jats:sup>\n                    into cells. Cd\n                    <jats:sup>2+<\/jats:sup>\n                    and other toxic nonessential metals can displace essential cations, thereby entering vertebrate cells. Whereas Slc39a8 encodes a single protein, Slc39a14 has 2 exons 4 which, via alternative splicing, give rise to ZIP14A and ZIP14B; why differences exist in cell type-specific expression of ZIP14A and ZIP14B remains unknown. Inflammatory stimuli have been associated with upregulation of ZIP8 and ZIP14, but a systematic study of many tissues simultaneously in a laboratory animal following inflammatory cytokine exposure has not yet been reported. Herein, we show that C57BL\/6J male mice\u2013\u2013treated intraperitoneally with lipopolysaccharide or the proinflammatory cytokines tumor necrosis factor (TNF) or interleukin-6 (IL6)\u2013\u2013exhibited quantatively very different, highly tissue-specific, and markedly time-dependent up- and downregulation of ZIP8, ZIP14A, and ZIP14B messenger RNA (mRNA) levels in 12 tissues. The magnitude of inflammatory response was confirmed by measuring the proinflammatory cytokine TNF, IL6, and interleukin-1\u03b2 mRNA levels in the same tissues of these animals. Our data suggest that most if not all tissues use ZIP8, ZIP14A, and\/or ZIP14B for Zn\n                    <jats:sup>2+<\/jats:sup>\n                    uptake, some tissues under basal conditions and others moreso when inflammatory stressors are present; collectively, this might lead to substantial alterations in plasma Zn\n                    <jats:sup>2+<\/jats:sup>\n                    levels due to Zn\n                    <jats:sup>2+<\/jats:sup>\n                    redistribution not just in liver but across many vital organs. In the context of cadmium-mediated toxicity, our data suggest that tissues other than liver, kidney, and lung should also be considered.\n                  <\/jats:p>","DOI":"10.1177\/1091581814529310","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T22:45:09Z","timestamp":1397256309000},"page":"246-258","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation\/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals"],"prefix":"10.1177","volume":"33","author":[{"given":"Marina","family":"G\u00e1lvez-Peralta","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA"},{"name":"Present address: Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA"},{"name":"Present address: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang Province, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengying","family":"Bao","sequence":"additional","affiliation":[{"name":"David Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daren L.","family":"Knoell","sequence":"additional","affiliation":[{"name":"David Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Nebert","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"bibr1-1091581814529310","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-143-37380"},{"key":"bibr2-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200003000-00006"},{"key":"bibr3-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406085102"},{"key":"bibr4-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.024521"},{"key":"bibr5-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.11.067"},{"key":"bibr6-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00409.2006"},{"key":"bibr7-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.02.017"},{"key":"bibr8-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.043588"},{"key":"bibr9-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1039\/c2mt20177a"},{"key":"bibr10-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00057.2008"},{"key":"bibr11-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.367284"},{"key":"bibr12-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-012-9526-x"},{"key":"bibr13-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1039\/c2mt20024d"},{"key":"bibr14-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606424103"},{"key":"bibr15-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.143248"},{"key":"bibr16-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00479.2010"},{"key":"bibr17-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036055"},{"key":"bibr18-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2002.7000"},{"key":"bibr19-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502257102"},{"key":"bibr20-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1208759"},{"key":"bibr21-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018059"},{"key":"bibr22-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048679"},{"key":"bibr23-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00385.2011"},{"key":"bibr24-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.01.009"},{"key":"bibr25-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0559-y"},{"key":"bibr26-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.007"},{"key":"bibr27-1091581814529310","doi-asserted-by":"publisher","DOI":"10.2741\/1341"},{"key":"bibr28-1091581814529310","doi-asserted-by":"publisher","DOI":"10.2741\/1690"},{"key":"bibr29-1091581814529310","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0431"}],"container-title":["International 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