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It plays an important role in acute carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    )-induced liver injury and regeneration in mice. In this study, we investigated the role of BPOZ2 in the process of liver fibrosis induced by chronic CCl\n                    <jats:sub>4<\/jats:sub>\n                    treatment. The results indicate that BPOZ2 deficiency decreases sustained activation of hepatic stellate cells, attenuates collagen \u03b1I(I) and tissue inhibitor of matrix metalloprotease 1 expression, and decreases liver fibrosis after repeated CCl\n                    <jats:sub>4<\/jats:sub>\n                    administration. These findings suggest BPOZ2 as a new therapeutic target for the prevention and treatment of hepatic fibrosis in chronic liver disease.\n                  <\/jats:p>","DOI":"10.1177\/1091581814566472","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T05:32:13Z","timestamp":1420695133000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon Tetrachloride Administration in Mice"],"prefix":"10.1177","volume":"34","author":[{"given":"Feng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Quzhou People's Hospital, Quzhou, Zhejiang, China"},{"name":"State Key Laboratory of Medical Genomics, Research Centre for Experimental Medicine of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Institute of Health 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