{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:32:04Z","timestamp":1793334724973,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Toxicol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Trichloroethylene (TCE) is a major occupational hazard and environmental contaminant that can cause multisystem disorders in the form of occupational medicamentosa-like dermatitis. Development of dermatitis involves several proinflammatory cytokines, but their role in TCE-mediated dermatitis has not been examined in a well-defined experimental model. In addition, few animal models of TCE sensitization are available, and the current guinea pig model has apparent limitations. This study aimed to establish a model of TCE-induced skin sensitization in BALB\/c mice and to examine the role of several key inflammatory cytokines on TCE sensitization. The sensitization rate of dorsal painted group was 38.3%. Skin edema and erythema occurred in TCE-sensitized groups, as seen in 2,4-dinitrochlorobenzene (DNCB) positive control. Trichloroethylene sensitization-positive (dermatitis [+]) group exhibited increased thickness of epidermis, inflammatory cell infiltration, swelling, and necrosis in dermis and around hair follicle, but ear painted group did not show these histological changes. The concentrations of serum proinflammatory cytokines including tumor necrosis factor (TNF)-\u03b1, interferon (IFN)-\u03b3, and interleukin (IL)-2 were significantly increased in 24, 48, and 72 hours dermatitis [+] groups treated with TCE and peaked at 72 hours. Deposition of TNF-\u03b1, IFN-\u03b3, and IL-2 into the skin tissue was also revealed by immunohistochemistry. We have established a new animal model of skin sensitization induced by repeated TCE stimulations, and we provide the first evidence that key proinflammatory cytokines including TNF-\u03b1, IFN-\u03b3, and IL-2 play an important role in the process of TCE sensitization.<\/jats:p>","DOI":"10.1177\/1091581815591222","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T23:01:22Z","timestamp":1435273282000},"page":"442-453","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["An Animal Model of Trichloroethylene-Induced Skin Sensitization in BALB\/c Mice"],"prefix":"10.1177","volume":"34","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-long","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-sheng","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China"},{"name":"Institute of Dermatology, Anhui Medical University, Hefei, Anhui, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Wu","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-xing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Anhui Medical University, Hefei, Anhui, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"bibr1-1091581815591222","first-page":"33","volume":"63","author":"Dry cleaning, some chlorinated solvents and other industrial chemicals","year":"1995","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"bibr2-1091581815591222","doi-asserted-by":"publisher","DOI":"10.3109\/10408440903222177"},{"key":"bibr3-1091581815591222","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.06.008"},{"key":"bibr4-1091581815591222","unstructured":"United States Environmental Protection Agency. Toxicological Review of Trichloroethylene. 2011. Web site. http:\/\/www.epa.gov\/iris\/supdocs\/0199index.html, Accessed December 2012. Updated 9, 2011. 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