{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:32:51Z","timestamp":1791325971436,"version":"4.3.1"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Toxicol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Vanadium is a metal present in particulate matter and its reprotoxic effects have been demonstrated in males and pregnant females in animal models. However, the effects of this metal on the reproductive organs of nonpregnant females have not been sufficiently studied. In a vanadium inhalation model in nonpregnant female mice, we found anestrous and estrous cycle irregularity, as well as low serum concentrations of 17\u03b2-estradiol and progesterone. A decrease in the diameter of secondary and preovulatory follicles, as well as a thickening of the myometrium and endometrial stroma, was observed in the vanadium-treated mice. There was no difference against the control group with respect to the presence of the estrogen receptor \u03b1 in the uterus of the animals during the estrous stage. Our results indicate that when vanadium is administered by inhalation, effects are observed on the female reproductive organs and the production of female sex hormones.<\/jats:p>","DOI":"10.1177\/1091581819894529","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T04:49:07Z","timestamp":1577681347000},"page":"20-29","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Changes in Ovarian and Uterine Morphology and Estrous Cycle in CD-1 Mice After Vanadium Inhalation"],"prefix":"10.1177","volume":"39","author":[{"given":"Nayeli","family":"Mel\u00e9ndez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Garc\u00eda-Ibarra","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Bizarro-Nevares","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Rojas-Lemus","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"L\u00f3pez-Valdez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Gonz\u00e1lez-Villalva","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Ayala-Escobar","sequence":"additional","affiliation":[{"name":"Laboratorio 5 Pubertad, Unidad de Investigaci\u00f3n en Biolog\u00eda de la Reproducci\u00f3n, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Garc\u00eda-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunogen\u00e9tica Molecular, Departamento de An\u00e1lisis Cl\u00ednicos y Estudios Especiales, Instituto Nacional de Pediatr\u00eda, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3507-1365","authenticated-orcid":false,"given":"Teresa I.","family":"Fortoul","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"key":"bibr1-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.05.005"},{"key":"bibr2-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.01.009"},{"key":"bibr3-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev330"},{"key":"bibr4-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.06.031"},{"key":"bibr5-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2012.05.007"},{"key":"bibr6-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2009.03.006"},{"key":"bibr7-1091581819894529","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.207472"},{"key":"bibr8-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.06.025"},{"key":"bibr9-1091581819894529","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S102230"},{"key":"bibr10-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2012.03.023"},{"issue":"6","key":"bibr11-1091581819894529","first-page":"120","volume":"11","author":"Chernyshev VV","year":"2018","journal-title":"Toxicol Rep"},{"key":"bibr12-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.08.090"},{"key":"bibr13-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715500114"},{"key":"bibr14-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/951043"},{"key":"bibr15-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(02)00241-4"},{"key":"bibr16-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6866(1996)16:1<7::AID-TCM2>3.0.CO;2-M"},{"key":"bibr17-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2873"},{"key":"bibr18-1091581819894529","first-page":"227","volume":"86","author":"International Agency for Research on Cancer","year":"2006","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"bibr19-1091581819894529","volume-title":"Concise International Chemical Assessment Document. Vanadium Pentoxide and Other Inorganic Vanadium Compounds","author":"World Health Organization","year":"2001"},{"key":"bibr20-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.nsa04is48"},{"key":"bibr21-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.10.011"},{"issue":"4","key":"bibr22-1091581819894529","first-page":"95","volume":"20","author":"Mills JN","year":"1979","journal-title":"Can Vet J"},{"key":"bibr23-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2004.06.013"},{"key":"bibr24-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21810"},{"key":"bibr25-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-2821-5"},{"key":"bibr26-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59453-2.00009-3"},{"key":"bibr27-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.10.017"},{"key":"bibr28-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.06.024"},{"key":"bibr29-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.10.027"},{"issue":"2","key":"bibr30-1091581819894529","first-page":"187","volume":"24","author":"Obianime AW","year":"2009","journal-title":"Niger J Physiol Sci"},{"key":"bibr31-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1191\/0748233705th232oa"},{"key":"bibr32-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713501364"},{"key":"bibr33-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-221054"},{"key":"bibr34-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1080\/10934521003708968"},{"key":"bibr35-1091581819894529","doi-asserted-by":"crossref","unstructured":"Knazicka Z, Forgacs J, Lukacova S, Roychoudhury P, Massanyi N, Lukac N. Endocrine disruptive effects of cadmium on steroidogenesis: human adrenocortical carcinoma cell line NCI-H295R as a cellular model for reproductive toxicity testing. J. Environ Sci Health A Tox Hazard Subst Environ Eng. 2015;50(4):348\u2013356. https:\/\/doi.org\/10.1080\/10934529.2015.987520.","DOI":"10.1080\/10934529.2015.987520"},{"key":"bibr36-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(90)90396-3"},{"key":"bibr37-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1021\/ic702405d"},{"key":"bibr38-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207207"},{"key":"bibr39-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00189.2002"},{"key":"bibr40-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod63.5.1331"},{"key":"bibr41-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013226107"},{"key":"bibr42-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-007-0294-y"},{"key":"bibr43-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713518600"},{"key":"bibr44-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2009.11.007"},{"key":"bibr45-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-1065-0"},{"key":"bibr46-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00054-0"},{"key":"bibr47-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1326"},{"key":"bibr48-1091581819894529","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122685"},{"key":"bibr49-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1080\/02772248.2015.1116072"},{"key":"bibr50-1091581819894529","doi-asserted-by":"publisher","DOI":"10.4067\/S0370-41062008000400004"},{"key":"bibr51-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010828200"},{"key":"bibr52-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.08.022"},{"key":"bibr53-1091581819894529","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1997.8254"}],"container-title":["International Journal of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1091581819894529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1091581819894529","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1091581819894529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:23:53Z","timestamp":1777458233000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1091581819894529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,30]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/1091581819894529"],"URL":"https:\/\/doi.org\/10.1177\/1091581819894529","relation":{},"ISSN":["1091-5818","1092-874X"],"issn-type":[{"value":"1091-5818","type":"print"},{"value":"1092-874X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,30]]}}}