{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:34:24Z","timestamp":1777718064007,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Toxicol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    The aim of this report was to evaluate the morphological and biochemical changes in the liver by the inhalation of vanadium and consumption of sweetened beverages in a subchronic murine model. Forty CD-1 male mice were randomly divided into four groups: control, vanadium (V), sucrose 30% (S), and vanadium\u2013sucrose (V + S). V was inhaled (1.4\u00a0mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    ) for 1h, twice\/week; 30% sucrose solution was given orally ad libitum. Blood samples were obtained for AST, ALT, and LDH determination. Liver samples were processed for histological and oxidative stress immunohistochemical evaluation with 4-hydroxynonenal at weeks 4 and 8 of exposure. Regarding liver function tests, a statistically significant increase ( P &lt; 0.05) was observed in groups V, S, and V + S at weeks 4 and 8 compared to the control group. A greater number of hepatocytes with meganuclei and binuclei were observed in V and V + S at week 8 compared to the other groups. Steatosis and regenerative changes were more extensive in the eighth week V + S group. 4-Hydroxynonenal immunoreactivity increased in the V + S group at both exposure times compared to the other groups; however, the increment was more evident in the V + S group at week 4 compared to the V + S group at week 8. An increase in De Ritis ratio (&gt;1) was noticed in experimental groups at weeks 4 and 8. Findings demonstrate that in the liver, V, S, and V + S induced oxidative stress and regenerative changes that increased with the length of exposure. Results support possible potentiation of liver damage in areas with high air pollution and high-sweetened beverage consumption.\n                  <\/jats:p>","DOI":"10.1177\/10915818211030858","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:38:35Z","timestamp":1626827915000},"page":"466-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Vanadium Inhalation and Sweetened Beverage Ingestion in Mice: Morphological and Biochemical Changes in the Liver"],"prefix":"10.1177","volume":"40","author":[{"given":"Mar\u00eda Eugenia","family":"Cervantes-Valencia","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de M\u00e9xico (UNAM), Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Gonz\u00e1lez-Villalva","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de M\u00e9xico (UNAM), Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gumaro","family":"Cano-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de M\u00e9xico (UNAM), Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Albarr\u00e1n-Alonso","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de M\u00e9xico (UNAM), Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3507-1365","authenticated-orcid":false,"given":"Teresa Imelda","family":"Fortoul","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Universidad Nacional Autonoma de M\u00e9xico (UNAM), Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"bibr1-10915818211030858","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.187"},{"key":"bibr2-10915818211030858","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-1568-2_2"},{"key":"bibr3-10915818211030858","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2015.03.018"},{"key":"bibr4-10915818211030858","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711412424"},{"key":"bibr5-10915818211030858","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-002-0376-9"},{"key":"bibr6-10915818211030858","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/951043"},{"key":"bibr7-10915818211030858","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.12.002"},{"key":"bibr8-10915818211030858","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16122192"},{"key":"bibr9-10915818211030858","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5278.38457"},{"key":"bibr10-10915818211030858","first-page":"117","volume":"34","author":"Botros M","year":"2013","journal-title":"Clin Biochem Rev"},{"key":"bibr11-10915818211030858","doi-asserted-by":"publisher","DOI":"10.1177\/1091581817745504"},{"key":"bibr12-10915818211030858","first-page":"227","volume":"86","author":"Cancer. 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