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The spontaneous incidence of central nervous system clinical signs in control animals from a single facility using cage-side observations or high definition video monitoring was retrospectively analyzed. Spontaneous convulsions were observed at low incidence in Beagle dogs and Sprague\u2013Dawley rats but were not identified in cynomolgus monkeys and G\u00f6ttingen minipigs. Spontaneous myoclonic jerks and muscle twitches were observed at low incidence in Beagle dogs, cynomolgus monkeys, and Sprague\u2013Dawley rats but were not seen in G\u00f6ttingen minipigs. Spontaneous ataxia\/incoordination was identified in all species and generally with a higher incidence when using video monitoring. Salivation and tremors were the two most frequent spontaneous clinical signs and both were observed in all species. Data from the current study unveil potential limitations when using control data obtained from a single study for toxicology interpretation related to low incidence neurological clinical signs while providing historical control data from Beagle dogs, cynomolgus monkeys, Sprague\u2013Dawley rats, and G\u00f6ttingen minipigs.<\/jats:p>","DOI":"10.1177\/10915818231218984","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T09:27:37Z","timestamp":1702027657000},"page":"123-133","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Spontaneous Incidence of Neurological Clinical Signs in Preclinical Species Using Cage-side Observations or High-definition Video Monitoring: A Retrospective Analysis"],"prefix":"10.1177","volume":"43","author":[{"given":"Chiara","family":"Orciani","sequence":"first","affiliation":[{"name":"Charles River, Laval, QC, 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