{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:32:52Z","timestamp":1786512772018,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aims to perform a comprehensive systematic review and meta-analysis to evaluate the impact of anticoagulation (AC) therapy on clinical outcomes during ventral hernia repair (VHR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A thorough online search was conducted using PubMed, Cochrane, and Embase databases. Studies comparing the use of AC therapy following VHR were included. The results analyzed were bleeding-related reoperation, hemorrhagic\/thrombotic complications, length of stay, and transfusion rates. Statistical analysis was performed with Review Manager 5.4 using a random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      From 1278 records, 4 studies were included, encompassing 41,868 patients (anticoagulants use = 4804; no AC = 32,649), with 25% on anticoagulant therapy submitted to minimally invasive surgery (MIS). Additionally, 90% of patients using anticoagulants underwent mesh placement. Overall analysis showed increased hemorrhagic\/thrombotic complications (risk ratios [RR]: 2.3; 95% confidence interval [CI]: 1.13\u20134.8;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02), bleeding-related reoperation (RR: 6.5; 95% CI: 4.3\u20139.9;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .00001), and longer hospital stays (mean difference: 1.69 days; 95% CI: .66 to 2.72 days;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001) in patients using anticoagulant medications. However, there was no increased risk of transfusion (RR: 2.14; 95% CI: 0.58\u20137.95;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .26) between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The use of anticoagulant therapy following VHR is associated with increased hemorrhagic\/thrombotic complications, bleeding-related reoperations, prolonged hospitalization, and similar transfusion rates. Further research is still required to validate these findings and explore the impact of MIS on anticoagulated patients following VHR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10926429251389911","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:41Z","timestamp":1761007481000},"page":"18-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Do Anticoagulants Have an Impact on the Clinical Outcomes of Ventral Hernia Repair? A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"36","author":[{"given":"Caroline Daleaste","family":"Wilmsen","sequence":"first","affiliation":[{"name":"Universidade do Planalto Catarinense, Lages, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Graziani e Sousa","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio de An\u00e1polis, An\u00e1polis, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Surgery, Montefiore Medical Center, Bronx, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Malcher","sequence":"additional","affiliation":[{"name":"Department of Surgery, Lenox Hill Hospital, Northwell, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Laurentino","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Surgery, Montefiore Medical Center, Bronx, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2023.04.007"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6127-y"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2478\/pjs-2014-0047"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2024.02.028"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2024.115856"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2022.01.023"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001213"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2024.03.013"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039471"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604.ch12"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2018.08.183"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2173-5077(09)70070-5"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5140-2"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-023-06899-5"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.04.001"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2020.0433"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-021-02481-x"}],"container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10926429251389911","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10926429251389911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10926429251389911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:21:26Z","timestamp":1786512086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10926429251389911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["10.1177\/10926429251389911"],"URL":"https:\/\/doi.org\/10.1177\/10926429251389911","relation":{},"ISSN":["1092-6429","1557-9034"],"issn-type":[{"value":"1092-6429","type":"print"},{"value":"1557-9034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]}}}