{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:03:34Z","timestamp":1784552614641,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Laparoendoscopic &amp; Advanced Surgical Techniques"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Complete mesocolic excision (CME) may increase lymph node retrieval and provide a more complete oncologic excision compared with D2 dissection, although its perioperative safety remains uncertain. This systematic review and Bayesian meta-analysis compared clinical and operative outcomes between CME and D2 in right colectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      PubMed, EMBASE, and Cochrane Central were searched through November 2025. Randomized controlled trials comparing CME with D2 were included. Frequentist analyses used random-effects models with DerSimonian-Laird estimation. Bayesian random-effects models applied weakly informative priors (binary outcomes: log[RR] \u223c N(0, 1.5\n                      <jats:sup>2<\/jats:sup>\n                      ), \u03c4 \u223c Half-Normal(0.5); blood loss: \u03bc \u223c N(0, 100\n                      <jats:sup>2<\/jats:sup>\n                      ), \u03c4 \u223c Half-Normal(100); lymph node yield: \u03bc \u223c N(0, 6\n                      <jats:sup>2<\/jats:sup>\n                      ), and \u03c4 \u223c Half-Normal(3)). Heterogeneity was assessed using\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      and Cochran\u2019s Q. Analyses were conducted in R (v4.4.2) with bayesmeta.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Three randomized trials (1378 patients; CME 678, D2 700) met inclusion criteria. CME resulted in higher lymph node harvest (MD + 3.9; 95% CI: 2.8 to 5.0;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and longer operative time (MD + 11.6 minutes; 95% CI: 6.6 to 16.7;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). No significant differences were found in blood loss, overall complications, severe complications, intraoperative complications, conversion, or 30-day mortality. Bayesian modeling provided very strong evidence for increased nodal yield (P[CME &gt; D2] = 99.1%) and hemostatic equivalence (P[equivalent \u00b1 50 mL] = 95.9%), with a modest probability favoring fewer severe complications (P[RR &lt; 1] = 82.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CME offers superior oncologic radicality, reflected by higher lymph node retrieval, while maintaining perioperative outcomes equivalent to D2. Bayesian evidence reinforces CME as an effective and safe surgical strategy for right-sided colon cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10926429261432594","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:51:46Z","timestamp":1773744706000},"page":"650-663","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Complete Mesocolic Excision Versus D2 Lymphadenectomy for Right Colon Cancer: A Bayesian Meta-Analysis of Randomized Trials Assessing Surgical and Perioperative Outcomes"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2960-3810","authenticated-orcid":false,"given":"Bernardo Fontel","family":"Pompeu","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, Heliopolis Hospital, S\u00e3o Paulo-SP, Brazil."},{"name":"USCS\u2014University of S\u00e3o Caetano do Sul, S\u00e3o Paulo-SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Monteiro","family":"Delgado","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Leal","family":"Barone","sequence":"additional","affiliation":[{"name":"USCS\u2014University of S\u00e3o Caetano do Sul, S\u00e3o Paulo-SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Barbaroto","family":"Pilon","sequence":"additional","affiliation":[{"name":"USCS\u2014University of S\u00e3o Caetano do Sul, S\u00e3o Paulo-SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Luiza","family":"Garcia","sequence":"additional","affiliation":[{"name":"USCS\u2014University of S\u00e3o Caetano do Sul, S\u00e3o Paulo-SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Viana","sequence":"additional","affiliation":[{"name":"University of the Extreme South of Santa Catarina, Crici\u00fama, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Theis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Mazzola","family":"Poli de Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Bellotti","family":"Formiga","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Heliopolis Hospital, S\u00e3o Paulo-SP, Brazil."},{"name":"Department of Colorectal Surgery, Hospital of Santa Casa de Miseric\u00f3rdia, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21772"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.06.022"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002323"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2624-4"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30485-1"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01735.x"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-021-08395-0"},{"issue":"1","key":"e_1_3_4_9_1","first-page":"1","article-title":"Propensity score-matched comparison between complete mesocolic excision and classic right hemicolectomy for colon cancer","volume":"73","author":"Lieto E","year":"2018","unstructured":"8.Lieto E, , Abdelkhalek M, , Orditura M, et al. 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